Association of Implantation Biopsy Findings in Living Donor Kidneys With Donor and Recipient Outcomes

Some living donor kidneys are found to have biopsy evidence of chronic scarring and/or glomerular disease at implantation, but it is unclear if these biopsy findings help predict donor kidney recovery or allograft outcomes. Our objective was to identify the prevalence of chronic histological changes...

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Veröffentlicht in:American journal of kidney diseases 2024-03, Vol.83 (3), p.306-317
Hauptverfasser: Emmons, Brendan R., Batal, Ibrahim, King, Kristen L., Yu, Miko, Canetta, Pietro A., Sandoval, P. Rodrigo, Mohan, Sumit, Tsapepas, Demetra, Adler, Joel T., Ratner, Lloyd E., Husain, S. Ali
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Sprache:eng
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Zusammenfassung:Some living donor kidneys are found to have biopsy evidence of chronic scarring and/or glomerular disease at implantation, but it is unclear if these biopsy findings help predict donor kidney recovery or allograft outcomes. Our objective was to identify the prevalence of chronic histological changes and glomerular disease in donor kidneys, and their association with donor and recipient outcomes. Retrospective cohort study. Single center, living donor kidney transplants from January 2010 to July 2022. Chronic histological changes, glomerular disease in donor kidney implantation biopsies. For donors, single-kidney estimated glomerular filtration rate (eGFR) increase, percent total eGFR loss, ≥40% eGFR decline from predonation baseline, and eGFR
ISSN:0272-6386
1523-6838
1523-6838
DOI:10.1053/j.ajkd.2023.08.022