3′‐Hydroxypterostilbene Potently Suppresses Tumor Growth via Inhibiting the Activation of the JAK2/STAT3 Pathway in Ovarian Clear Cell Carcinoma
Scope Ovarian clear cell carcinoma (OCCC) is a subtype of epithelial ovarian cancer (EOC) that is associated with higher interleukin‐6 (IL‐6) levels, and suppression of the Janus kinase 2/Signal transducer and activator of transription 3 (JAK2/STAT3) pathway may contribute to the suppression of this...
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| Veröffentlicht in: | Molecular nutrition & food research 2024-01, Vol.68 (1), p.e2300108-n/a |
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| creator | Koh, Yen‐Chun Huang, Wei‐Zhe Nagabhushanam, Kalyanam Ho, Chi‐Tang Pan, Min‐Hsiung |
| description | Scope
Ovarian clear cell carcinoma (OCCC) is a subtype of epithelial ovarian cancer (EOC) that is associated with higher interleukin‐6 (IL‐6) levels, and suppression of the Janus kinase 2/Signal transducer and activator of transription 3 (JAK2/STAT3) pathway may contribute to the suppression of this cancer. This study aims to compare the anti‐cancer effect of pterostilbene (PSB) and 2’‐ and 3’‐hydroxypterostilbene (2HPSB and 3HPSB, respectively) on the JAK2/STAT3 pathway.
Methods and results
In vitro experiments with the OCCC cell line TOV21G and a xenograft nude mouse model are used to achieve the study aims. The results showed that 3HPSB has the greatest anti‐proliferative and pro‐apoptotic effects of the three compounds studied. Activation of the JAK2/STAT3 pathway and the nuclear translocation of STAT3 are effectively inhibited by 3HPSB and PSB. Both 3HPSB and PSB can effectively suppress tumor growth, which is mediated by the inhibition of JAK2/STAT3 phosphorylation.
Conclusion
This is the first study to compare the efficacy of PSB, 3HPSB, and the newly identified compound 2HPSB regarding ovarian cancer. Moreover, targeting JAK2/STAT3 is shown to be a potentially effective strategy for OCCC treatment. This study is expected to provide new insights into the potential of the abovementioned phytochemicals for development as adjuvants for cancer treatment in the future.
Suppression of the JAK2/STAT3 pathway by 3’‐hydroxypterostilbene and pterostilbene may contribute to tumor growth inhibition in a xenograft nude mouse model. |
| doi_str_mv | 10.1002/mnfr.202300108 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2881712249</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2881712249</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3237-996005fefd12d2898b82bec68eade4c80ef50113aad132b4b2fdcc9636f64d5b3</originalsourceid><addsrcrecordid>eNqFkb1uFDEQxy0EIiHQUiJLNDR38dftR3lakQ8IJCJHbXm9Y87Rrr2xvXdsl0eg4El4pDwJGy5cQUM1o9Fv_hrND6HXlMwpIey4cybMGWGcEEqKJ-iQZpTPBOX86b5niwP0IsYbQjhlgj9HBzwv8owKfoh-8vu7X_d3P87GJvjvY58g-JhsW4MDfOUTuNSO-Hro-wAxQsSrofMBnwa_TWu8sQqfu7WtbbLuG05rwEud7EYl6x325s_kw_IjO75eLVccX6m03qoRW4cvNypY5XDVggq4grbFlQraOt-pl-iZUW2EV4_1CH09eb-qzmYXl6fn1fJipjnj-awsM0IWBkxDWcOKsqgLVoPOClANCF0QMAtCKVeqoZzVomam0brMeGYy0SxqfoTe7XL74G8HiEl2NurpFOXAD1GyoqA5ZUyUE_r2H_TGD8FN10lWTiYE4YRO1HxH6emLMYCRfbCdCqOkRD74kg--5N7XtPDmMXaoO2j2-F9BEyB2wNa2MP4nTn76fPJFZCTnvwGE-6QB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2910040301</pqid></control><display><type>article</type><title>3′‐Hydroxypterostilbene Potently Suppresses Tumor Growth via Inhibiting the Activation of the JAK2/STAT3 Pathway in Ovarian Clear Cell Carcinoma</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Koh, Yen‐Chun ; Huang, Wei‐Zhe ; Nagabhushanam, Kalyanam ; Ho, Chi‐Tang ; Pan, Min‐Hsiung</creator><creatorcontrib>Koh, Yen‐Chun ; Huang, Wei‐Zhe ; Nagabhushanam, Kalyanam ; Ho, Chi‐Tang ; Pan, Min‐Hsiung</creatorcontrib><description>Scope
Ovarian clear cell carcinoma (OCCC) is a subtype of epithelial ovarian cancer (EOC) that is associated with higher interleukin‐6 (IL‐6) levels, and suppression of the Janus kinase 2/Signal transducer and activator of transription 3 (JAK2/STAT3) pathway may contribute to the suppression of this cancer. This study aims to compare the anti‐cancer effect of pterostilbene (PSB) and 2’‐ and 3’‐hydroxypterostilbene (2HPSB and 3HPSB, respectively) on the JAK2/STAT3 pathway.
Methods and results
In vitro experiments with the OCCC cell line TOV21G and a xenograft nude mouse model are used to achieve the study aims. The results showed that 3HPSB has the greatest anti‐proliferative and pro‐apoptotic effects of the three compounds studied. Activation of the JAK2/STAT3 pathway and the nuclear translocation of STAT3 are effectively inhibited by 3HPSB and PSB. Both 3HPSB and PSB can effectively suppress tumor growth, which is mediated by the inhibition of JAK2/STAT3 phosphorylation.
Conclusion
This is the first study to compare the efficacy of PSB, 3HPSB, and the newly identified compound 2HPSB regarding ovarian cancer. Moreover, targeting JAK2/STAT3 is shown to be a potentially effective strategy for OCCC treatment. This study is expected to provide new insights into the potential of the abovementioned phytochemicals for development as adjuvants for cancer treatment in the future.
Suppression of the JAK2/STAT3 pathway by 3’‐hydroxypterostilbene and pterostilbene may contribute to tumor growth inhibition in a xenograft nude mouse model.</description><identifier>ISSN: 1613-4125</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.202300108</identifier><identifier>PMID: 37876143</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>3’‐hydoxypterostilbene ; Adjuvants ; Animals ; Apoptosis ; Cancer ; Cancer therapies ; Carcinoma ; Cell Line, Tumor ; Cell Proliferation ; Female ; Humans ; In vitro methods and tests ; Interleukin 6 ; JAK2/STAT3 ; Janus kinase ; Janus kinase 2 ; Janus Kinase 2 - metabolism ; Janus Kinase 2 - pharmacology ; Kinases ; Mice ; Nuclear transport ; Ovarian cancer ; Ovarian carcinoma ; ovarian clear cell carcinoma ; Ovarian Neoplasms - drug therapy ; Ovarian Neoplasms - metabolism ; Ovarian Neoplasms - pathology ; Phosphorylation ; pterostilbene ; Stat3 protein ; STAT3 Transcription Factor - metabolism ; Translocation ; Tumors ; xenograft ; Xenotransplantation</subject><ispartof>Molecular nutrition & food research, 2024-01, Vol.68 (1), p.e2300108-n/a</ispartof><rights>2023 Wiley‐VCH GmbH</rights><rights>2023 Wiley-VCH GmbH.</rights><rights>2024 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3237-996005fefd12d2898b82bec68eade4c80ef50113aad132b4b2fdcc9636f64d5b3</cites><orcidid>0000-0002-5188-7030 ; 0000-0001-7683-873X ; 0000-0001-9470-4110</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.202300108$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.202300108$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37876143$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koh, Yen‐Chun</creatorcontrib><creatorcontrib>Huang, Wei‐Zhe</creatorcontrib><creatorcontrib>Nagabhushanam, Kalyanam</creatorcontrib><creatorcontrib>Ho, Chi‐Tang</creatorcontrib><creatorcontrib>Pan, Min‐Hsiung</creatorcontrib><title>3′‐Hydroxypterostilbene Potently Suppresses Tumor Growth via Inhibiting the Activation of the JAK2/STAT3 Pathway in Ovarian Clear Cell Carcinoma</title><title>Molecular nutrition & food research</title><addtitle>Mol Nutr Food Res</addtitle><description>Scope
Ovarian clear cell carcinoma (OCCC) is a subtype of epithelial ovarian cancer (EOC) that is associated with higher interleukin‐6 (IL‐6) levels, and suppression of the Janus kinase 2/Signal transducer and activator of transription 3 (JAK2/STAT3) pathway may contribute to the suppression of this cancer. This study aims to compare the anti‐cancer effect of pterostilbene (PSB) and 2’‐ and 3’‐hydroxypterostilbene (2HPSB and 3HPSB, respectively) on the JAK2/STAT3 pathway.
Methods and results
In vitro experiments with the OCCC cell line TOV21G and a xenograft nude mouse model are used to achieve the study aims. The results showed that 3HPSB has the greatest anti‐proliferative and pro‐apoptotic effects of the three compounds studied. Activation of the JAK2/STAT3 pathway and the nuclear translocation of STAT3 are effectively inhibited by 3HPSB and PSB. Both 3HPSB and PSB can effectively suppress tumor growth, which is mediated by the inhibition of JAK2/STAT3 phosphorylation.
Conclusion
This is the first study to compare the efficacy of PSB, 3HPSB, and the newly identified compound 2HPSB regarding ovarian cancer. Moreover, targeting JAK2/STAT3 is shown to be a potentially effective strategy for OCCC treatment. This study is expected to provide new insights into the potential of the abovementioned phytochemicals for development as adjuvants for cancer treatment in the future.
Suppression of the JAK2/STAT3 pathway by 3’‐hydroxypterostilbene and pterostilbene may contribute to tumor growth inhibition in a xenograft nude mouse model.</description><subject>3’‐hydoxypterostilbene</subject><subject>Adjuvants</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Carcinoma</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation</subject><subject>Female</subject><subject>Humans</subject><subject>In vitro methods and tests</subject><subject>Interleukin 6</subject><subject>JAK2/STAT3</subject><subject>Janus kinase</subject><subject>Janus kinase 2</subject><subject>Janus Kinase 2 - metabolism</subject><subject>Janus Kinase 2 - pharmacology</subject><subject>Kinases</subject><subject>Mice</subject><subject>Nuclear transport</subject><subject>Ovarian cancer</subject><subject>Ovarian carcinoma</subject><subject>ovarian clear cell carcinoma</subject><subject>Ovarian Neoplasms - drug therapy</subject><subject>Ovarian Neoplasms - metabolism</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Phosphorylation</subject><subject>pterostilbene</subject><subject>Stat3 protein</subject><subject>STAT3 Transcription Factor - metabolism</subject><subject>Translocation</subject><subject>Tumors</subject><subject>xenograft</subject><subject>Xenotransplantation</subject><issn>1613-4125</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb1uFDEQxy0EIiHQUiJLNDR38dftR3lakQ8IJCJHbXm9Y87Rrr2xvXdsl0eg4El4pDwJGy5cQUM1o9Fv_hrND6HXlMwpIey4cybMGWGcEEqKJ-iQZpTPBOX86b5niwP0IsYbQjhlgj9HBzwv8owKfoh-8vu7X_d3P87GJvjvY58g-JhsW4MDfOUTuNSO-Hro-wAxQsSrofMBnwa_TWu8sQqfu7WtbbLuG05rwEud7EYl6x325s_kw_IjO75eLVccX6m03qoRW4cvNypY5XDVggq4grbFlQraOt-pl-iZUW2EV4_1CH09eb-qzmYXl6fn1fJipjnj-awsM0IWBkxDWcOKsqgLVoPOClANCF0QMAtCKVeqoZzVomam0brMeGYy0SxqfoTe7XL74G8HiEl2NurpFOXAD1GyoqA5ZUyUE_r2H_TGD8FN10lWTiYE4YRO1HxH6emLMYCRfbCdCqOkRD74kg--5N7XtPDmMXaoO2j2-F9BEyB2wNa2MP4nTn76fPJFZCTnvwGE-6QB</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Koh, Yen‐Chun</creator><creator>Huang, Wei‐Zhe</creator><creator>Nagabhushanam, Kalyanam</creator><creator>Ho, Chi‐Tang</creator><creator>Pan, Min‐Hsiung</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5188-7030</orcidid><orcidid>https://orcid.org/0000-0001-7683-873X</orcidid><orcidid>https://orcid.org/0000-0001-9470-4110</orcidid></search><sort><creationdate>202401</creationdate><title>3′‐Hydroxypterostilbene Potently Suppresses Tumor Growth via Inhibiting the Activation of the JAK2/STAT3 Pathway in Ovarian Clear Cell Carcinoma</title><author>Koh, Yen‐Chun ; Huang, Wei‐Zhe ; Nagabhushanam, Kalyanam ; Ho, Chi‐Tang ; Pan, Min‐Hsiung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3237-996005fefd12d2898b82bec68eade4c80ef50113aad132b4b2fdcc9636f64d5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>3’‐hydoxypterostilbene</topic><topic>Adjuvants</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Carcinoma</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation</topic><topic>Female</topic><topic>Humans</topic><topic>In vitro methods and tests</topic><topic>Interleukin 6</topic><topic>JAK2/STAT3</topic><topic>Janus kinase</topic><topic>Janus kinase 2</topic><topic>Janus Kinase 2 - metabolism</topic><topic>Janus Kinase 2 - pharmacology</topic><topic>Kinases</topic><topic>Mice</topic><topic>Nuclear transport</topic><topic>Ovarian cancer</topic><topic>Ovarian carcinoma</topic><topic>ovarian clear cell carcinoma</topic><topic>Ovarian Neoplasms - drug therapy</topic><topic>Ovarian Neoplasms - metabolism</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Phosphorylation</topic><topic>pterostilbene</topic><topic>Stat3 protein</topic><topic>STAT3 Transcription Factor - metabolism</topic><topic>Translocation</topic><topic>Tumors</topic><topic>xenograft</topic><topic>Xenotransplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koh, Yen‐Chun</creatorcontrib><creatorcontrib>Huang, Wei‐Zhe</creatorcontrib><creatorcontrib>Nagabhushanam, Kalyanam</creatorcontrib><creatorcontrib>Ho, Chi‐Tang</creatorcontrib><creatorcontrib>Pan, Min‐Hsiung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koh, Yen‐Chun</au><au>Huang, Wei‐Zhe</au><au>Nagabhushanam, Kalyanam</au><au>Ho, Chi‐Tang</au><au>Pan, Min‐Hsiung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>3′‐Hydroxypterostilbene Potently Suppresses Tumor Growth via Inhibiting the Activation of the JAK2/STAT3 Pathway in Ovarian Clear Cell Carcinoma</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol Nutr Food Res</addtitle><date>2024-01</date><risdate>2024</risdate><volume>68</volume><issue>1</issue><spage>e2300108</spage><epage>n/a</epage><pages>e2300108-n/a</pages><issn>1613-4125</issn><eissn>1613-4133</eissn><abstract>Scope
Ovarian clear cell carcinoma (OCCC) is a subtype of epithelial ovarian cancer (EOC) that is associated with higher interleukin‐6 (IL‐6) levels, and suppression of the Janus kinase 2/Signal transducer and activator of transription 3 (JAK2/STAT3) pathway may contribute to the suppression of this cancer. This study aims to compare the anti‐cancer effect of pterostilbene (PSB) and 2’‐ and 3’‐hydroxypterostilbene (2HPSB and 3HPSB, respectively) on the JAK2/STAT3 pathway.
Methods and results
In vitro experiments with the OCCC cell line TOV21G and a xenograft nude mouse model are used to achieve the study aims. The results showed that 3HPSB has the greatest anti‐proliferative and pro‐apoptotic effects of the three compounds studied. Activation of the JAK2/STAT3 pathway and the nuclear translocation of STAT3 are effectively inhibited by 3HPSB and PSB. Both 3HPSB and PSB can effectively suppress tumor growth, which is mediated by the inhibition of JAK2/STAT3 phosphorylation.
Conclusion
This is the first study to compare the efficacy of PSB, 3HPSB, and the newly identified compound 2HPSB regarding ovarian cancer. Moreover, targeting JAK2/STAT3 is shown to be a potentially effective strategy for OCCC treatment. This study is expected to provide new insights into the potential of the abovementioned phytochemicals for development as adjuvants for cancer treatment in the future.
Suppression of the JAK2/STAT3 pathway by 3’‐hydroxypterostilbene and pterostilbene may contribute to tumor growth inhibition in a xenograft nude mouse model.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37876143</pmid><doi>10.1002/mnfr.202300108</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-5188-7030</orcidid><orcidid>https://orcid.org/0000-0001-7683-873X</orcidid><orcidid>https://orcid.org/0000-0001-9470-4110</orcidid></addata></record> |
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| subjects | 3’‐hydoxypterostilbene Adjuvants Animals Apoptosis Cancer Cancer therapies Carcinoma Cell Line, Tumor Cell Proliferation Female Humans In vitro methods and tests Interleukin 6 JAK2/STAT3 Janus kinase Janus kinase 2 Janus Kinase 2 - metabolism Janus Kinase 2 - pharmacology Kinases Mice Nuclear transport Ovarian cancer Ovarian carcinoma ovarian clear cell carcinoma Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Phosphorylation pterostilbene Stat3 protein STAT3 Transcription Factor - metabolism Translocation Tumors xenograft Xenotransplantation |
| title | 3′‐Hydroxypterostilbene Potently Suppresses Tumor Growth via Inhibiting the Activation of the JAK2/STAT3 Pathway in Ovarian Clear Cell Carcinoma |
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