Selective and controllable amination and defluoroamidation of α-trifluoromethylstyrene

We present a blueprint for the amination and defluoroamidation of α-trifluoromethylstyrene. This practical protocol presents a general method for the diversity-oriented synthesis of vicinal trifluoromethyl amines and gem -difluoro alkenes from α-trifluoromethylstyrene maintaining excellent chemoselectivity. The synthetic strategy features outstanding atom economy and wide functional group tolerance under mild reaction conditions. Selective and controllable amination and defluoroamidation of α-trifluoromethylstyrene was achieved with moderate to excellent yield, which features outstanding atom-economical and wide functional group tolerance under mild reaction conditions.