Emerging trends in sensors based on molecular imprinting technology: Harnessing smartphones for portable detection and recognition

Molecular imprinting technology (MIT) has become a promising recognition technology in various fields due to its specificity, high efficiency, stability and eco-friendliness in the recognition of target. Molecularly imprinted polymers (MIPs), known as ‘artificial receptors', are shown similar properties to natural receptors as a biomimetic material. The selectivity of recognition for targets can be greatly improved when MIPs are introduced into sensors, as known that MIPs, are suitable for the pretreatment and analysis of trace substances in complex matrix samples. At present, various sensors has been developed by the combination with MIPs for detecting and identifying trace compounds, biological macromolecules or other substances, such as optical, electrochemical and piezoelectric sensors. Smart phones, with their built-in sensors and powerful digital imaging capabilities, provide a unique platform for the needs of portability and instant detection. MIP sensors based on smart phones are expected to become a new research direction in the future. This review discusses the latest applications of MIP sensors in the field of detection and recognition in recent years, summarizes the frontier progress of MIP sensor research based on smart phones in the past two years, and points out the challenges, limitations and future development prospects. [Display omitted] •MIP has been widely applied due to its high specificity, stability, and other advantages.•Sensors based on MIP are fast, sensitive, and highly specific.•Sensors based on MIP mainly include electrochemical and optical sensors.•Smartphones achieve better portability and meet the needs of real-time detection.