Fork restart: unloading FANCD2 to travel ahead

Fork restart: unloading FANCD2 to travel ahead

In this issue of Molecular Cell, Brunner et al.1 reveal that eliminating FANCD2 from stalled forks via FBXL12-mediated degradation enables cells to tolerate oncogene-induced replication stress, making FBXL12 a promising target for cancer treatment.

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Veröffentlicht in:Molecular cell 2023-10, Vol.83 (20), p.3590-3592
Hauptverfasser: Iyer, Divya R., D’Andrea, Alan D.
Format: Artikel
Sprache:eng
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Zusammenfassung:In this issue of Molecular Cell, Brunner et al.1 reveal that eliminating FANCD2 from stalled forks via FBXL12-mediated degradation enables cells to tolerate oncogene-induced replication stress, making FBXL12 a promising target for cancer treatment.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2023.09.027