Virological outcomes of various first-line ART regimens in patients harbouring HIV-1 E157Q integrase polymorphism: a multicentre retrospective study

Virological outcomes of various first-line ART regimens in patients harbouring HIV-1 E157Q integrase polymorphism: a multicentre retrospective study

Abstract Background Integrase strand transfer inhibitors (INSTIs) are recommended as first-line ART for people living with HIV (PLWH) in most guidelines. The INSTI-resistance-associated mutation E157Q, a highly prevalent (2%–5%) polymorphism of the HIV-1 (human immunodeficiency virus type 1) integra...

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Veröffentlicht in:Journal of antimicrobial chemotherapy 2023-12, Vol.78 (12), p.2859-2868
Hauptverfasser: Uno, Shunsuke, Gatanaga, Hiroyuki, Hayashida, Tsunefusa, Imahashi, Mayumi, Minami, Rumi, Koga, Michiko, Samukawa, Sei, Watanabe, Dai, Fujii, Teruhisa, Tateyama, Masao, Nakamura, Hideta, Matsushita, Shuzo, Yoshino, Yusuke, Endo, Tomoyuki, Horiba, Masahide, Taniguchi, Toshibumi, Moro, Hiroshi, Igari, Hidetoshi, Yoshida, Shigeru, Teshima, Takanori, Nakajima, Hideaki, Nishizawa, Masako, Yokomaku, Yoshiyuki, Iwatani, Yasumasa, Hachiya, Atsuko, Kato, Shingo, Hasegawa, Naoki, Yoshimura, Kazuhisa, Sugiura, Wataru, Kikuchi, Tadashi
Format: Artikel
Sprache:eng
Schlagworte:
Drug Resistance, Viral - genetics
Heterocyclic Compounds, 3-Ring - therapeutic use
HIV Infections - drug therapy
HIV Integrase - genetics
HIV Integrase Inhibitors - pharmacology
HIV Integrase Inhibitors - therapeutic use
HIV-1 - genetics
Humans
Raltegravir Potassium - therapeutic use
Retrospective Studies
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Zusammenfassung:Abstract Background Integrase strand transfer inhibitors (INSTIs) are recommended as first-line ART for people living with HIV (PLWH) in most guidelines. The INSTI-resistance-associated mutation E157Q, a highly prevalent (2%–5%) polymorphism of the HIV-1 (human immunodeficiency virus type 1) integrase gene, has limited data on optimal first-line ART regimens. We assessed the virological outcomes of various first-line ART regimens in PLWH with E157Q in real-world settings. Methods A multicentre retrospective observational study was conducted on PLWH who underwent integrase genotypic drug-resistance testing before ART initiation between 2008 and 2019 and were found to have E157Q. Viral suppression (
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkad319