Angiogenesis related genes in Takayasu Arteritis (TAK): robust association with Tag SNPs of IL-18 and FGF-2 in a South Asian Cohort

We performed genetic association study for genes encoding angiogenic and angiostatic proteins in patients with Takayasu arteritis (TAK). A total of 96 SNPs involving 60 genes were studied. Genotyping was performed in Fluidigm 96.96 Dynamic Array chip. All statistical analysis for SNP evaluation was...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of human genetics 2024-01, Vol.69 (1), p.13-18
Hauptverfasser:	Danda, Debashish, Goel, Ruchika, Kabeerdoss, Jayakanthan, Sun, Celi, Danda, Sumita, Lincy Franklin, Anisea, Joseph, George, Nath, Swapan K
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Angiogenesis Angiopoietin Arteritis Coronary artery Fibroblast growth factor 2 Fibroblast Growth Factor 2 - genetics Genes Genetic analysis Genetic Predisposition to Disease Genomes Genotypes Genotyping Humans Interleukin 18 Interleukin-18 - genetics Linkage disequilibrium Phenotypes Polymorphism, Single Nucleotide Single-nucleotide polymorphism Statistical analysis Takayasu Arteritis - genetics Takayasu's disease Vein & artery diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We performed genetic association study for genes encoding angiogenic and angiostatic proteins in patients with Takayasu arteritis (TAK). A total of 96 SNPs involving 60 genes were studied. Genotyping was performed in Fluidigm 96.96 Dynamic Array chip. All statistical analysis for SNP evaluation was performed using PLINK software. Initial analyses revealed five SNPs from three genes [IL-18 (encodes Interleukin-18), FGF2 (encodes Fibroblast Growth Factor-2), and ANGPT1 (encodes Angiopoietin-1)] as significantly different between controls and cases (uncorrected p
ISSN:	1434-5161 1435-232X
DOI:	10.1038/s10038-023-01198-2