Subphenotypes of severe early‐onset pre‐eclampsia at hospital admission. A Latin American single‐center exploratory latent class analysis

Objectives To identify distinct subphenotypes of severe early‐onset pre‐eclampsia in Latin America and analyze biomarker and hemodynamic trends between subphenotypes after hospital admission. Methods A single‐center prospective cohort study was conducted in Colombia. The latent class analysis identified subphenotypes using clinical variables, biomarkers, laboratory tests, and maternal hemodynamics. Class‐defining variables were restricted to measurements at and 24 h after admission. Primary and secondary outcomes were severe maternal and perinatal complications. Results Among 49 patients, two subphenotypes were identified: Subphenotype 1 (34.7%) had a higher likelihood of an sFlt‐1/PlGF ratio ≤ 38, maternal age > 35, and low probability of TPR > 1400, CO 1400, CO