Feasibility, Safety, and Efficacy of Aggressive Multimodal Management of Elderly Patients With Pancreatic Ductal Adenocarcinoma

To evaluate the safety and efficacy of neoadjuvant therapy (NAT), followed by surgical resection in patients with pancreatic ductal adenocarcinoma (PDAC) aged ≥75 years. Whether administration of NAT, followed by surgical resection in elderly patients with PDAC is safe and effective is unknown. The...

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Veröffentlicht in:	Annals of surgery 2024-07, Vol.280 (1), p.118-125
Hauptverfasser:	Qiao, Guoliang, Fong, Zhi Ven, Bolm, Louisa, Fernandez Del-Castillo, Carlos, Ferrone, Cristina R, Servin-Rojas, Maximiliano, Pathak, Priyadarshini, Lau-Min, Kelsey, Allen, Jill N, Blaszkowsky, Lawrence S, Clark, Jeffrey W, Parikh, Aparna R, Ryan, David P, Weekes, Colin D, Roberts, Hannah M, Wo, Jennifer Y, Hong, Theodore S, Lillemoe, Keith D, Qadan, Motaz
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carcinoma, Pancreatic Ductal - mortality Carcinoma, Pancreatic Ductal - surgery Carcinoma, Pancreatic Ductal - therapy Feasibility Studies Female Fluorouracil - administration & dosage Fluorouracil - therapeutic use Humans Irinotecan - administration & dosage Irinotecan - therapeutic use Leucovorin - administration & dosage Leucovorin - therapeutic use Male Middle Aged Neoadjuvant Therapy Oxaliplatin - administration & dosage Oxaliplatin - therapeutic use Pancreatectomy Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Pancreatic Neoplasms - therapy Propensity Score Retrospective Studies Treatment Outcome
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Zusammenfassung:	To evaluate the safety and efficacy of neoadjuvant therapy (NAT), followed by surgical resection in patients with pancreatic ductal adenocarcinoma (PDAC) aged ≥75 years. Whether administration of NAT, followed by surgical resection in elderly patients with PDAC is safe and effective is unknown. The present study is a three-part comparison of older (≥75 years) versus younger (
ISSN:	0003-4932 1528-1140
DOI:	10.1097/SLA.0000000000006131