Exploring the role of PI3K/AKT/mTOR inhibitors in hormone-related cancers: A focus on breast and prostate cancer

Breast cancer (BC) and prostate cancer (PC) are at the top of the list when it comes to the most common types of cancers worldwide. The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is important, in that it strongly influences the development and progression of these tumors. Previous studies have emphasized the key role of inhibitors of the PIK3/AKT/mTOR signaling pathway in the treatment of BC and PC, and it remains to be a crucial method of treatment. In this review, the inhibitors of these signaling pathways are compared, as well as their effectiveness in therapy and potential as therapeutic agents. The use of these inhibitors as polytherapy is evaluated, especially with the use of hormonal therapy, which has shown promising results. [Display omitted] •The PI3K/AKT/mTOR pathway is one of the most crucial signaling pathways in cells.•Mutations in this pathway commonly contribute to the development of breast and prostate cancer.•The inhibitors targeting the PI3K/AKT/mTOR signaling pathway represent promising therapeutic targets.•Polytherapy involving inhibitors, in conjunction with hormonal therapy, demonstrates encouraging outcomes.