Quantitative assessment of breast volume changes after whole-breast irradiation for breast cancer using breast auto-segmentation

Quantitative assessment of breast volume changes after whole-breast irradiation for breast cancer using breast auto-segmentation

Purpose This study aimed to quantitatively estimate the changes in breast volume associated with radiotherapy in patients undergoing breast-conserving surgery and whole-breast irradiation (WBI). Methods Pre-WBI simulation computed tomography (CT) scans and post-WBI follow-up chest CT scans from a to...

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Veröffentlicht in:Breast cancer research and treatment 2024, Vol.203 (2), p.205-214
Hauptverfasser: Lee, Tae Hoon, Ahn, Sang Hee, Chung, Kwangzoo, Park, Won, Cho, Won Kyung, Kim, Nalee, Kim, Tae Gyu, Kim, Haeyoung
Format: Artikel
Sprache:eng
Schlagworte:
Asymmetry
Breast cancer
Cancer research
Clinical Trial
Computed tomography
CT imaging
Lumpectomy
Medical imaging
Medicine
Medicine & Public Health
Oncology
Radiation therapy
Radiotherapy
Regression analysis
Segmentation
Statistical analysis
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Zusammenfassung:Purpose This study aimed to quantitatively estimate the changes in breast volume associated with radiotherapy in patients undergoing breast-conserving surgery and whole-breast irradiation (WBI). Methods Pre-WBI simulation computed tomography (CT) scans and post-WBI follow-up chest CT scans from a total of 1,151 breast cancer patients were analyzed using a deep-learning-driven auto-segmentation approach. The CT-based asymmetry index (CTAI) was calculated by dividing the volume of the irradiated breast by the volume of the contralateral breast. Significant breast shrinkage was defined as a CTAI 
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-023-07146-0