Efficacy and Toxicity of Calcitonin Treatment in Children with Cherubism: A Single‐Center Cohort Study

ABSTRACT Cherubism is a rare autosomal dominant disease characterized by expansile osteolytic jawbone lesions. The effect and safety of off‐label calcitonin treatment during the progressive phase of the disease are not well described. In this retrospective study, we present data on the radiological...

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Veröffentlicht in:	Journal of bone and mineral research 2023-12, Vol.38 (12), p.1822-1833
Hauptverfasser:	Schreuder, Willem H., Meijer, Ethan B., Cleven, Arjen H.G., Edelenbos, Esther, Klop, Cornelis, Schreurs, Ruud, Jong, Renate T., Maarle, Merel C., Horsthuis, Roy B.G., Lange, Jan, Berg, Henk
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcitonin Calcitonin - adverse effects Cells of bone—osteoclasts Cherubism - drug therapy Child Children Cohort analysis Cohort Studies Dental biology Diseases and disorders of/related to bone—cherubism Drug therapy Female Humans Hypocalcemia Jaw Lesions Male Minerals Molecular pathways—development Osteolysis Retrospective Studies Side effects Statistical analysis Therapeutics—calcitonin Toxicity
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Zusammenfassung:	ABSTRACT Cherubism is a rare autosomal dominant disease characterized by expansile osteolytic jawbone lesions. The effect and safety of off‐label calcitonin treatment during the progressive phase of the disease are not well described. In this retrospective study, we present data on the radiological response and adverse effects of subcutaneously administered calcitonin in a cohort of nine cherubism children (three female, six male). Two of the nine patients underwent two separate treatment courses with a significant off‐treatment interval in between; therefore, a total of 11 treatment courses with a mean duration of 17.9 months (range
ISSN:	0884-0431 1523-4681
DOI:	10.1002/jbmr.4922