Pig-to-primate organ transplants require genetic modifications of donor
A raft of alterations to the pig genome — removing three antigen-encoding genes, adding seven human genes and eliminating a retrovirus — allows kidneys to be transplanted into monkeys, with implications for clinical trials. Genetic engineering for pig-to-primate kidney transplants. Credit: Cristine...
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| Veröffentlicht in: | Nature (London) 2023-10, Vol.622 (7982), p.244-245 |
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| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | A raft of alterations to the pig genome — removing three antigen-encoding genes, adding seven human genes and eliminating a retrovirus — allows kidneys to be transplanted into monkeys, with implications for clinical trials.
Genetic engineering for pig-to-primate kidney transplants.
Credit: Cristine Heaps, PhD, Texas A&M University
Yucatán miniature pigs in a research facility at Texas A&M university |
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| ISSN: | 0028-0836 1476-4687 |
| DOI: | 10.1038/d41586-023-02817-w |