Total Fertilization Failure: A Single Center Analysis

Our main objective was to identify the male and female parameters associated with total fertilization failure (TFF) in IVF with nonmasculine indications. The present work, IRB equivalent INS 63209, is a case–control study that evaluated all cases with TFF after conventional IVF at the Center for Human Reproduction from January 2010 to December 2019 ( n = 154). As a control group, we analyzed all patients who did not experience fertilization failure after conventional IVF in the same period ( n = 475). We evaluated various parameters, both male and female, assessed during infertility treatment, and only cases without masculine etiology (normal seminal parameters) were included. Ages (female and male) were not different between the groups. Moreover, AMH (anti-Müllerian hormone), semen volume, preprocessing concentration and preprocessing motility were not significantly different ( P > 0.05). However, the number of collected oocytes (study versus control groups, median [25–75 interquartile]: 2 [1–5] and 5 [3–8]); MII (2 [1–4] and 5 [2–7]); and postprocessing motility (85 [70–90] and 90 [80–95]) were significantly different between both groups ( P