Prognostic factors for multisystem inflammatory syndrome in children: A systematic review and meta‐analysis

Aim Multisystem inflammatory syndrome in children (MIS‐C) is a novel condition that can occur post‐SARS‐CoV‐2 infection in children and adolescents. There is a paucity of evidence on the prognostic factors associated with MIS‐C. The aim of this systematic review and meta‐analysis was to summarise the prognostic factors for MIS‐C development. Methods Five databases were systematically searched from January 2020 to May 2023 for studies reporting on prognostic factors for MIS‐C using multivariable regression models. Random‐effects meta‐analyses were conducted to pool odds ratios for each prognostic factor. Risk of bias was rated using QUIPS and the GRADE framework was used to assess the certainty of evidence for each unique factor. Results Twelve observational studies (N = 18 024) were included, and 13 unique prognostic factors were amenable to meta‐analysis. With moderate certainty, age