Structural insights into an intracellular biased agonist for GPCRs

The targeting and modulation of G-protein-coupled receptors (GPCRs) has immense therapeutic potential. A study in Nature now reports on the successful targeting of intracellular allosteric sites that effectively bias GPCR signaling, which has opened new opportunities to develop safer therapeutic age...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature structural & molecular biology 2023-11, Vol.30 (11), p.1612-1614
Hauptverfasser:	Soni, Neeraj, Das, Tarumoy, Baidya, Mithu
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154 631/45/612/194 Allosteric properties Binding sites Biochemistry Biological Microscopy Biomedical and Life Sciences Drugs G protein-coupled receptors Intracellular Intracellular signalling Life Sciences Ligands Membrane Biology Molecular biology News & Views news-and-views Pharmacology Protein Structure Receptors, G-Protein-Coupled - chemistry Signal Transduction Trends
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!