Structural insights into an intracellular biased agonist for GPCRs

Structural insights into an intracellular biased agonist for GPCRs

The targeting and modulation of G-protein-coupled receptors (GPCRs) has immense therapeutic potential. A study in Nature now reports on the successful targeting of intracellular allosteric sites that effectively bias GPCR signaling, which has opened new opportunities to develop safer therapeutic age...

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Veröffentlicht in:Nature structural & molecular biology 2023-11, Vol.30 (11), p.1612-1614
Hauptverfasser: Soni, Neeraj, Das, Tarumoy, Baidya, Mithu
Format: Artikel
Sprache:eng
Schlagworte:
631/154
631/45/612/194
Allosteric properties
Binding sites
Biochemistry
Biological Microscopy
Biomedical and Life Sciences
Drugs
G protein-coupled receptors
Intracellular
Intracellular signalling
Life Sciences
Ligands
Membrane Biology
Molecular biology
News & Views
news-and-views
Pharmacology
Protein Structure
Receptors, G-Protein-Coupled - chemistry
Signal Transduction
Trends
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Beschreibung
Zusammenfassung:The targeting and modulation of G-protein-coupled receptors (GPCRs) has immense therapeutic potential. A study in Nature now reports on the successful targeting of intracellular allosteric sites that effectively bias GPCR signaling, which has opened new opportunities to develop safer therapeutic agents.
ISSN:1545-9993
1545-9985
DOI:10.1038/s41594-023-01100-w