Structural insights into an intracellular biased agonist for GPCRs
The targeting and modulation of G-protein-coupled receptors (GPCRs) has immense therapeutic potential. A study in Nature now reports on the successful targeting of intracellular allosteric sites that effectively bias GPCR signaling, which has opened new opportunities to develop safer therapeutic age...
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| Veröffentlicht in: | Nature structural & molecular biology 2023-11, Vol.30 (11), p.1612-1614 |
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| container_end_page | 1614 |
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| container_issue | 11 |
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| container_title | Nature structural & molecular biology |
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| creator | Soni, Neeraj Das, Tarumoy Baidya, Mithu |
| description | The targeting and modulation of G-protein-coupled receptors (GPCRs) has immense therapeutic potential. A study in
Nature
now reports on the successful targeting of intracellular allosteric sites that effectively bias GPCR signaling, which has opened new opportunities to develop safer therapeutic agents. |
| doi_str_mv | 10.1038/s41594-023-01100-w |
| format | Article |
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| source | MEDLINE; SpringerLink Journals; Nature Journals Online |
| subjects | 631/154 631/45/612/194 Allosteric properties Binding sites Biochemistry Biological Microscopy Biomedical and Life Sciences Drugs G protein-coupled receptors Intracellular Intracellular signalling Life Sciences Ligands Membrane Biology Molecular biology News & Views news-and-views Pharmacology Protein Structure Receptors, G-Protein-Coupled - chemistry Signal Transduction Trends |
| title | Structural insights into an intracellular biased agonist for GPCRs |
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