INFLUENCE OF VASCULAR STENT SURFACE TREATMENT WITH AN ADAPTIVE COMPOSITION FOR IMPROVING ITS BIOCOMPATIBILITY AND RESTENOSIS PREVENTION

AIMthe article describes a method of implant surface treatment that reduces the risk of an inflammatory reaction to vascular implants. The research was conducted on 34 male rabbits of the "Flemish Giant" breed weighing 2.5-3.0 kg, following the standards of bioethical principles. The blood vessels of the experimental animals were previously provoked by the administration of endogenous pyrogenic solution according to a predetermined protocol. Under general anesthesia, the animals were endovascularly (via femoral access into the abdominal aorta) implanted with standard Z-shaped stents made of 316L stainless steel. To obtain indicative results, 10 rabbits were implanted with non-treated stents, while another 12 rabbits had stents pre-treated with the adapting composition (AdC) implanted. After 8 weeks, the animals were withdrawn from the experiment. Vessel wall morphometry revealed that the treatment of stents with AdC before their placement into the vessel resulted in a reduction of vessel wall thickness at the site of their implantation. The clinical application of AdC aimed at improving the biocompatibility properties of implants with respect to the recipient's body is characterized by a 100% (95% CI 78.2% - 100%) likelihood of absence of complications.