Low‐grade inflammation for predicting severe acute pancreatitis in patients with hypertriglyceridemic acute pancreatitis

ObjectivesWe aimed to evaluate the association between low‐grade inflammation (LGI) and the severity of hypertriglyceridemic acute pancreatitis (HTG‐AP).MethodsWe retrospectively reviewed 311 patients with HTG‐AP who were admitted to the Department of Gastroenterology, Fujian Provincial Hospital between April 2012 and March 2021. Inpatient medical and radiological records were reviewed to collect the clinical manifestations, disease severity, and comorbidities. C‐reactive protein (CRP) level, white blood cell (WBC) count, platelet (PLT) count, and neutrophil‐to‐lymphocyte ratio (NLR) were considered LGI components and were combined to calculate a standardized LGI score. The association between the LGI score and the severity of HTG‐AP was analyzed using univariate and multivariate logistic regression analyses.ResultsOf the 311 patients with HTG‐AP, 47 (15.1%) had mild acute pancreatitis (MAP), 184 (59.2%) had moderately severe acute pancreatitis (MSAP), and 80 (25.7%) had severe acute pancreatitis (SAP), respectively. Patients with MSAP and SAP had a higher LGI score than those with MAP (1.50 vs −6.00, P