A dihydro-benzo[4,5]imidazo[1,2-]quinazoline-based probe with aggregation-induced ratiometric emission for the ratiometric fluorescent detection of peroxynitrite in living cells and zebrafish

A dihydro-benzo[4,5]imidazo[1,2-]quinazoline-based probe with aggregation-induced ratiometric emission for the ratiometric fluorescent detection of peroxynitrite in living cells and zebrafish

As a significant kind of reactive oxygen species (ROS), peroxynitrite (ONOO − ) plays an indispensable role in many physiological and pathological processes. This study aimed to synthesize a novel dihydro-benzo[4,5]imidazo[1,2- c ]quinazoline-based probe 1 for detecting ONOO − . In 99.5% H 2 O solut...

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Veröffentlicht in:Analytical methods 2023-10, Vol.15 (4), p.5311-5315
Hauptverfasser: Yan, Jin-Long, Liu, Shuang-Shuang, Wu, Wei-Na, Zhao, Xiao-Lei, Fan, Yun-Chang, Wang, Yuan, Xu, Zhi-Hong
Format: Artikel
Sprache:eng
Schlagworte:
Danio rerio
Emission
Emissions
Fluorescence
Peroxynitrite
Reactive oxygen species
Zebrafish
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Zusammenfassung:As a significant kind of reactive oxygen species (ROS), peroxynitrite (ONOO − ) plays an indispensable role in many physiological and pathological processes. This study aimed to synthesize a novel dihydro-benzo[4,5]imidazo[1,2- c ]quinazoline-based probe 1 for detecting ONOO − . In 99.5% H 2 O solution, probe 1 displayed a distinct aggregation-induced ratiometric emission (AIRE), and would selectively respond toward ONOO − via a ratiometric fluorescent signal, along with a short response time (
ISSN:1759-9660
1759-9679
DOI:10.1039/d3ay01416a