Anteroseptal accessory pathways: Killing one bird with two stones

Background and Aims Ablation of anteroseptal accessory pathways (AS‐AP) is challenging, with lower success and more complications compared to other APs. AS‐APs can be successfully ablated from the right atrium (RA) or the aortic valve's noncoronary cusp (NCC). We report two patients who required a hybrid ablation approach to achieve successful abolition of both anterograde and retrograde AS‐AP conduction. Methods and Results A 21‐year‐old female with supraventricular tachycardia (SVT) and pre‐excitation on electrocardiogram (ECG) underwent electrophysiology study (EPS) confirming an AS‐AP with anterograde and retrograde conduction. Ablation in the NCC achieved immediate and persistent anterograde conduction block. Electrophysiological maneuvers showed persistent retrograde AP conduction and orthodromic reciprocating tachycardia (ORT) remained easily inducible. Additional ablation in the NCC did not eliminate retrograde conduction. Further ablation in the RA opposite the NCC at the site of earliest retrograde atrial activation during ORT restored sinus and eliminated retrograde AP conduction. A 52‐year‐old male with SVT and ECG with pre‐excitation underwent EPS that confirmed an AS‐AP with anterograde and retrograde conduction. Ablation was performed in the NCC resulting in immediate elimination of pre‐excitation. Retrograde conduction was still present and confirmed by repeating electrophysiological maneuvers. Ablation was performed in the RA opposite the successful ablation site in the NCC, eliminating retrograde AP conduction. Conclusion Two cases of AS‐AP with anterograde and retrograde conduction and successful elimination of pathway conduction required a hybrid ablation approach from the NCC and RA. This approach may be helpful in other cases to improve success rates without using excessive ablation near the normal conduction system.