Recent Advances in Photochemical Asymmetric Three‐Component Reactions

Over the past decades, asymmetric photochemical synthesis has garnered significant attention for its sustainability and unique ability to generate enantio‐enriched molecules through distinct reaction pathways. Photochemical asymmetric three‐component reactions have demonstrated significant potential for the rapid construction of chiral compounds with molecular diversity and complexity. However, noteworthy challenges persist, including the participation of high‐energy intermediates such as radical species, difficulties in precise control of stereoselectivity, and the presence of competing background and side reactions. Recent breakthroughs have led to the development of sophisticated strategies in this field. This review explores the intricate mechanisms, synthetic applications, and limitations of these methods. We anticipate that it will contribute towards advancing asymmetric catalysis, photochemical synthesis, and green chemistry. This review primarily revolves around the photochemical asymmetric three‐component transformations facilitated by transition metal catalysis or organocatalysis. The intricate reaction mechanisms, diverse synthetic applications, and inherent limitations of these methods are thoroughly examined and discussed.