Increased expression levels of DLX5 inhibit the development of the nervous system

Increased expression levels of DLX5 inhibit the development of the nervous system

Introduction Preeclampsia is a hypertensive disorder of pregnancy. DLX5 plays an important role in the migration and differentiation of subglobus pallidus precursor cells. Methods We established a zebrafish line expressing high levels of DLX5 and investigated changes in behavior and development of t...

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Veröffentlicht in:International journal of developmental neuroscience 2023-12, Vol.83 (8), p.728-739
Hauptverfasser: Liao, Tingting, Xu, Xia, Wu, Junzi, Xie, Yi, Yan, Jianying
Format: Artikel
Sprache:eng
Schlagworte:
DLX5
nervous system
offspring
pre‐eclampsia
zebrafish
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Zusammenfassung:Introduction Preeclampsia is a hypertensive disorder of pregnancy. DLX5 plays an important role in the migration and differentiation of subglobus pallidus precursor cells. Methods We established a zebrafish line expressing high levels of DLX5 and investigated changes in behavior and development of the nervous system. Results The ratios of brain volume area to whole body area at 96 hpf zebrafish in the experimental group (gRNA + CasRx) were significantly lower than the WT group and the negative control group (casRx) (P 
ISSN:0736-5748
1873-474X
DOI:10.1002/jdn.10300