Predictors of non‐transplantable recurrence in hepatocellular carcinoma patients treated with frontline liver resection
Background and Aims Hepatocellular carcinoma (HCC) recurrence is common in patients treated with liver resection (LR). In this study, we aimed to evaluate the incidence and preoperative predictors of non‐transplantable recurrence in patients with single HCC ≤5 cm treated with frontline LR. Methods F...
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| Veröffentlicht in: | Liver international 2023-12, Vol.43 (12), p.2762-2775 |
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| creator | Pelizzaro, Filippo Trevisani, Franco Simeon, Vittorio Vitale, Alessandro Cillo, Umberto Piscaglia, Fabio Missale, Gabriele Sangiovanni, Angelo Foschi, Francesco G. Cabibbo, Giuseppe Caturelli, Eugenio Di Marco, Maria Azzaroli, Francesco Brunetto, Maurizia R. Raimondo, Giovanni Vidili, Gianpaolo Guarino, Maria Gasbarrini, Antonio Campani, Claudia Svegliati‐Baroni, Gianluca Giannini, Edoardo G. Mega, Andrea Masotto, Alberto Rapaccini, Gian Ludovico Magalotti, Donatella Sacco, Rodolfo Nardone, Gerardo Farinati, Fabio Biselli, Maurizio Caraceni, Paolo Lani, Lorenzo Rampoldi, Davide Reggidori, Nicola Santi, Valentina Stefanini, Benedetta Granito, Alessandro Muratori, Luca Sansone, Vito Tovoli, Francesco Dajti, Elton Marasco, Giovanni Ravaioli, Federico Cappelli, Alberta Golfieri, Rita Mosconi, Cristina Renzulli, Matteo Pinto, Elisa Palano, Giorgio Kitenge, Maria Piera Bertellini, Federica Cela, Ester Marina Facciorusso, Antonio Pieri, Giulia Torres, Maria Corina Plaz Pasta, Andrea Matthaeis, Nicoletta Ponziani, Francesca Romana Ghittoni, Giorgia Lauria, Valentina Pelecca, Giorgio Chegai, Fabrizio Raso, Armando Bozzi, Alessio Biasini, Elisabetta Olivani, Andrea Inno, Alessandro Marchetti, Fabiana Celsa, Ciro Giuffrida, Paolo Giacchetto, Carmelo Marco Rancatore, Gabriele Grassini, Maria Vittoria Ciccia, Roberta Grova, Alessandro Salvato, Mauro Franzè, Maria Stella Saitta, Carlo Arru, Marco Sauchella, Assunta Serra, Maria Grazia Bevilacqua, Vittoria Borghi, Alberto Gardini, Andrea Casadei Conti, Fabio Dall’Aglio, Anna Chiara Ercolani, Giorgio Mirici, Federica Marra, Fabio Adotti, Valentina Rosi, Martina Coccoli, Pietro Malerba, Antonio Morisco, Filomena Cossiga, Valentina Capasso, Mario Romagnoli, Veronica |
| description | Background and Aims
Hepatocellular carcinoma (HCC) recurrence is common in patients treated with liver resection (LR). In this study, we aimed to evaluate the incidence and preoperative predictors of non‐transplantable recurrence in patients with single HCC ≤5 cm treated with frontline LR.
Methods
From the Italian Liver Cancer (ITA.LI.CA) database, 512 patients receiving frontline LR for single HCC ≤5 cm were retrieved. Incidence and predictors of recurrence beyond Milan criteria (MC) and up‐to‐seven criteria were compared between patients with HCC |
| doi_str_mv | 10.1111/liv.15719 |
| format | Article |
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Trevisani, Franco ; Simeon, Vittorio ; Vitale, Alessandro ; Cillo, Umberto ; Piscaglia, Fabio ; Missale, Gabriele ; Sangiovanni, Angelo ; Foschi, Francesco G. ; Cabibbo, Giuseppe ; Caturelli, Eugenio ; Di Marco, Maria ; Azzaroli, Francesco ; Brunetto, Maurizia R. ; Raimondo, Giovanni ; Vidili, Gianpaolo ; Guarino, Maria ; Gasbarrini, Antonio ; Campani, Claudia ; Svegliati‐Baroni, Gianluca ; Giannini, Edoardo G. ; Mega, Andrea ; Masotto, Alberto ; Rapaccini, Gian Ludovico ; Magalotti, Donatella ; Sacco, Rodolfo ; Nardone, Gerardo ; Farinati, Fabio ; Biselli, Maurizio ; Caraceni, Paolo ; Lani, Lorenzo ; Rampoldi, Davide ; Reggidori, Nicola ; Santi, Valentina ; Stefanini, Benedetta ; Granito, Alessandro ; Muratori, Luca ; Sansone, Vito ; Tovoli, Francesco ; Dajti, Elton ; Marasco, Giovanni ; Ravaioli, Federico ; Cappelli, Alberta ; Golfieri, Rita ; Mosconi, Cristina ; Renzulli, Matteo ; Pinto, Elisa ; Palano, Giorgio ; Kitenge, Maria Piera ; Bertellini, Federica ; Cela, Ester Marina ; Facciorusso, Antonio ; Pieri, Giulia ; Torres, Maria Corina Plaz ; Pasta, Andrea ; Matthaeis, Nicoletta ; Ponziani, Francesca Romana ; Ghittoni, Giorgia ; Lauria, Valentina ; Pelecca, Giorgio ; Chegai, Fabrizio ; Raso, Armando ; Bozzi, Alessio ; Biasini, Elisabetta ; Olivani, Andrea ; Inno, Alessandro ; Marchetti, Fabiana ; Celsa, Ciro ; Giuffrida, Paolo ; Giacchetto, Carmelo Marco ; Rancatore, Gabriele ; Grassini, Maria Vittoria ; Ciccia, Roberta ; Grova, Alessandro ; Salvato, Mauro ; Franzè, Maria Stella ; Saitta, Carlo ; Arru, Marco ; Sauchella, Assunta ; Serra, Maria Grazia ; Bevilacqua, Vittoria ; Borghi, Alberto ; Gardini, Andrea Casadei ; Conti, Fabio ; Dall’Aglio, Anna Chiara ; Ercolani, Giorgio ; Mirici, Federica ; Marra, Fabio ; Adotti, Valentina ; Rosi, Martina ; Coccoli, Pietro ; Malerba, Antonio ; Morisco, Filomena ; Cossiga, Valentina ; Capasso, Mario ; Romagnoli, Veronica</creator><creatorcontrib>Pelizzaro, Filippo ; Trevisani, Franco ; Simeon, Vittorio ; Vitale, Alessandro ; Cillo, Umberto ; Piscaglia, Fabio ; Missale, Gabriele ; Sangiovanni, Angelo ; Foschi, Francesco G. ; Cabibbo, Giuseppe ; Caturelli, Eugenio ; Di Marco, Maria ; Azzaroli, Francesco ; Brunetto, Maurizia R. ; Raimondo, Giovanni ; Vidili, Gianpaolo ; Guarino, Maria ; Gasbarrini, Antonio ; Campani, Claudia ; Svegliati‐Baroni, Gianluca ; Giannini, Edoardo G. ; Mega, Andrea ; Masotto, Alberto ; Rapaccini, Gian Ludovico ; Magalotti, Donatella ; Sacco, Rodolfo ; Nardone, Gerardo ; Farinati, Fabio ; Biselli, Maurizio ; Caraceni, Paolo ; Lani, Lorenzo ; Rampoldi, Davide ; Reggidori, Nicola ; Santi, Valentina ; Stefanini, Benedetta ; Granito, Alessandro ; Muratori, Luca ; Sansone, Vito ; Tovoli, Francesco ; Dajti, Elton ; Marasco, Giovanni ; Ravaioli, Federico ; Cappelli, Alberta ; Golfieri, Rita ; Mosconi, Cristina ; Renzulli, Matteo ; Pinto, Elisa ; Palano, Giorgio ; Kitenge, Maria Piera ; Bertellini, Federica ; Cela, Ester Marina ; Facciorusso, Antonio ; Pieri, Giulia ; Torres, Maria Corina Plaz ; Pasta, Andrea ; Matthaeis, Nicoletta ; Ponziani, Francesca Romana ; Ghittoni, Giorgia ; Lauria, Valentina ; Pelecca, Giorgio ; Chegai, Fabrizio ; Raso, Armando ; Bozzi, Alessio ; Biasini, Elisabetta ; Olivani, Andrea ; Inno, Alessandro ; Marchetti, Fabiana ; Celsa, Ciro ; Giuffrida, Paolo ; Giacchetto, Carmelo Marco ; Rancatore, Gabriele ; Grassini, Maria Vittoria ; Ciccia, Roberta ; Grova, Alessandro ; Salvato, Mauro ; Franzè, Maria Stella ; Saitta, Carlo ; Arru, Marco ; Sauchella, Assunta ; Serra, Maria Grazia ; Bevilacqua, Vittoria ; Borghi, Alberto ; Gardini, Andrea Casadei ; Conti, Fabio ; Dall’Aglio, Anna Chiara ; Ercolani, Giorgio ; Mirici, Federica ; Marra, Fabio ; Adotti, Valentina ; Rosi, Martina ; Coccoli, Pietro ; Malerba, Antonio ; Morisco, Filomena ; Cossiga, Valentina ; Capasso, Mario ; Romagnoli, Veronica ; Italian Liver Cancer (ITA.LI.CA) group ; for the Italian Liver Cancer (ITA.LI.CA) group</creatorcontrib><description>Background and Aims
Hepatocellular carcinoma (HCC) recurrence is common in patients treated with liver resection (LR). In this study, we aimed to evaluate the incidence and preoperative predictors of non‐transplantable recurrence in patients with single HCC ≤5 cm treated with frontline LR.
Methods
From the Italian Liver Cancer (ITA.LI.CA) database, 512 patients receiving frontline LR for single HCC ≤5 cm were retrieved. Incidence and predictors of recurrence beyond Milan criteria (MC) and up‐to‐seven criteria were compared between patients with HCC <4 and ≥4 cm.
Results
During a median follow‐up of 4.2 years, the overall recurrence rate was 55.9%. In the ≥4 cm group, a significantly higher proportion of patients recurred beyond MC at first recurrence (28.9% vs. 14.1%; p < 0.001) and overall (44.4% vs. 25.2%; p < 0.001). Similar results were found considering recurrence beyond up‐to‐seven criteria. Compared to those with larger tumours, patients with HCC <4 cm had a longer recurrence‐free survival and overall survival. HCC size ≥4 cm and high alpha‐fetoprotein (AFP) level at the time of LR were independent predictors of recurrence beyond MC (and up‐to‐seven criteria). In the subgroup of patients with available histologic information (n = 354), microvascular invasion and microsatellite lesions were identified as additional independent risk factors for non‐transplantable recurrence.
Conclusions
Despite the high recurrence rate, LR for single HCC ≤5 cm offers excellent long‐term survival. Non‐transplantable recurrence is predicted by HCC size and AFP levels, among pre‐operatively available variables. High‐risk patients could be considered for frontline LT or listed for transplantation even before recurrence.</description><identifier>ISSN: 1478-3223</identifier><identifier>EISSN: 1478-3231</identifier><identifier>DOI: 10.1111/liv.15719</identifier><identifier>PMID: 37753540</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>alpha-Fetoproteins ; Carcinoma, Hepatocellular ; Criteria ; hepatectomy ; Hepatectomy - methods ; Hepatocellular carcinoma ; Humans ; Liver ; Liver cancer ; Liver Neoplasms - pathology ; Liver Transplantation ; Microvasculature ; Neoplasm Recurrence, Local - pathology ; recurrence ; Retrospective Studies ; Risk factors ; Subgroups ; Survival ; Transplantation ; Tumors ; tumour size</subject><ispartof>Liver international, 2023-12, Vol.43 (12), p.2762-2775</ispartof><rights>2023 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2023 The Authors. Liver International published by John Wiley & Sons Ltd.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3889-956b2529876b1318ac4d5dc089c637332f0f4e52ccc20825c9bcb10a2e37f3163</citedby><cites>FETCH-LOGICAL-c3889-956b2529876b1318ac4d5dc089c637332f0f4e52ccc20825c9bcb10a2e37f3163</cites><orcidid>0000-0003-4399-3359 ; 0000-0002-8903-5829 ; 0000-0001-8344-6523 ; 0000-0003-3112-8587 ; 0000-0002-0460-4122 ; 0000-0002-6393-6995 ; 0000-0003-0584-1442 ; 0000-0003-4863-6924 ; 0000-0001-8264-1845 ; 0000-0002-9996-9385 ; 0000-0001-8364-9152 ; 0000-0003-3842-782X ; 0000-0001-6691-8701 ; 0000-0002-2944-1374 ; 0000-0002-4548-8308 ; 0000-0001-8526-837X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fliv.15719$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fliv.15719$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37753540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pelizzaro, Filippo</creatorcontrib><creatorcontrib>Trevisani, Franco</creatorcontrib><creatorcontrib>Simeon, Vittorio</creatorcontrib><creatorcontrib>Vitale, Alessandro</creatorcontrib><creatorcontrib>Cillo, Umberto</creatorcontrib><creatorcontrib>Piscaglia, Fabio</creatorcontrib><creatorcontrib>Missale, Gabriele</creatorcontrib><creatorcontrib>Sangiovanni, Angelo</creatorcontrib><creatorcontrib>Foschi, Francesco G.</creatorcontrib><creatorcontrib>Cabibbo, Giuseppe</creatorcontrib><creatorcontrib>Caturelli, Eugenio</creatorcontrib><creatorcontrib>Di Marco, Maria</creatorcontrib><creatorcontrib>Azzaroli, Francesco</creatorcontrib><creatorcontrib>Brunetto, Maurizia R.</creatorcontrib><creatorcontrib>Raimondo, Giovanni</creatorcontrib><creatorcontrib>Vidili, Gianpaolo</creatorcontrib><creatorcontrib>Guarino, Maria</creatorcontrib><creatorcontrib>Gasbarrini, Antonio</creatorcontrib><creatorcontrib>Campani, Claudia</creatorcontrib><creatorcontrib>Svegliati‐Baroni, Gianluca</creatorcontrib><creatorcontrib>Giannini, Edoardo G.</creatorcontrib><creatorcontrib>Mega, Andrea</creatorcontrib><creatorcontrib>Masotto, Alberto</creatorcontrib><creatorcontrib>Rapaccini, Gian Ludovico</creatorcontrib><creatorcontrib>Magalotti, Donatella</creatorcontrib><creatorcontrib>Sacco, Rodolfo</creatorcontrib><creatorcontrib>Nardone, Gerardo</creatorcontrib><creatorcontrib>Farinati, Fabio</creatorcontrib><creatorcontrib>Biselli, Maurizio</creatorcontrib><creatorcontrib>Caraceni, Paolo</creatorcontrib><creatorcontrib>Lani, Lorenzo</creatorcontrib><creatorcontrib>Rampoldi, Davide</creatorcontrib><creatorcontrib>Reggidori, Nicola</creatorcontrib><creatorcontrib>Santi, Valentina</creatorcontrib><creatorcontrib>Stefanini, Benedetta</creatorcontrib><creatorcontrib>Granito, Alessandro</creatorcontrib><creatorcontrib>Muratori, Luca</creatorcontrib><creatorcontrib>Sansone, Vito</creatorcontrib><creatorcontrib>Tovoli, Francesco</creatorcontrib><creatorcontrib>Dajti, Elton</creatorcontrib><creatorcontrib>Marasco, Giovanni</creatorcontrib><creatorcontrib>Ravaioli, Federico</creatorcontrib><creatorcontrib>Cappelli, Alberta</creatorcontrib><creatorcontrib>Golfieri, Rita</creatorcontrib><creatorcontrib>Mosconi, Cristina</creatorcontrib><creatorcontrib>Renzulli, Matteo</creatorcontrib><creatorcontrib>Pinto, Elisa</creatorcontrib><creatorcontrib>Palano, Giorgio</creatorcontrib><creatorcontrib>Kitenge, Maria Piera</creatorcontrib><creatorcontrib>Bertellini, Federica</creatorcontrib><creatorcontrib>Cela, Ester Marina</creatorcontrib><creatorcontrib>Facciorusso, Antonio</creatorcontrib><creatorcontrib>Pieri, Giulia</creatorcontrib><creatorcontrib>Torres, Maria Corina Plaz</creatorcontrib><creatorcontrib>Pasta, Andrea</creatorcontrib><creatorcontrib>Matthaeis, Nicoletta</creatorcontrib><creatorcontrib>Ponziani, Francesca Romana</creatorcontrib><creatorcontrib>Ghittoni, Giorgia</creatorcontrib><creatorcontrib>Lauria, Valentina</creatorcontrib><creatorcontrib>Pelecca, Giorgio</creatorcontrib><creatorcontrib>Chegai, Fabrizio</creatorcontrib><creatorcontrib>Raso, Armando</creatorcontrib><creatorcontrib>Bozzi, Alessio</creatorcontrib><creatorcontrib>Biasini, Elisabetta</creatorcontrib><creatorcontrib>Olivani, Andrea</creatorcontrib><creatorcontrib>Inno, Alessandro</creatorcontrib><creatorcontrib>Marchetti, Fabiana</creatorcontrib><creatorcontrib>Celsa, Ciro</creatorcontrib><creatorcontrib>Giuffrida, Paolo</creatorcontrib><creatorcontrib>Giacchetto, Carmelo Marco</creatorcontrib><creatorcontrib>Rancatore, Gabriele</creatorcontrib><creatorcontrib>Grassini, Maria Vittoria</creatorcontrib><creatorcontrib>Ciccia, Roberta</creatorcontrib><creatorcontrib>Grova, Alessandro</creatorcontrib><creatorcontrib>Salvato, Mauro</creatorcontrib><creatorcontrib>Franzè, Maria Stella</creatorcontrib><creatorcontrib>Saitta, Carlo</creatorcontrib><creatorcontrib>Arru, Marco</creatorcontrib><creatorcontrib>Sauchella, Assunta</creatorcontrib><creatorcontrib>Serra, Maria Grazia</creatorcontrib><creatorcontrib>Bevilacqua, Vittoria</creatorcontrib><creatorcontrib>Borghi, Alberto</creatorcontrib><creatorcontrib>Gardini, Andrea Casadei</creatorcontrib><creatorcontrib>Conti, Fabio</creatorcontrib><creatorcontrib>Dall’Aglio, Anna Chiara</creatorcontrib><creatorcontrib>Ercolani, Giorgio</creatorcontrib><creatorcontrib>Mirici, Federica</creatorcontrib><creatorcontrib>Marra, Fabio</creatorcontrib><creatorcontrib>Adotti, Valentina</creatorcontrib><creatorcontrib>Rosi, Martina</creatorcontrib><creatorcontrib>Coccoli, Pietro</creatorcontrib><creatorcontrib>Malerba, Antonio</creatorcontrib><creatorcontrib>Morisco, Filomena</creatorcontrib><creatorcontrib>Cossiga, Valentina</creatorcontrib><creatorcontrib>Capasso, Mario</creatorcontrib><creatorcontrib>Romagnoli, Veronica</creatorcontrib><creatorcontrib>Italian Liver Cancer (ITA.LI.CA) group</creatorcontrib><creatorcontrib>for the Italian Liver Cancer (ITA.LI.CA) group</creatorcontrib><title>Predictors of non‐transplantable recurrence in hepatocellular carcinoma patients treated with frontline liver resection</title><title>Liver international</title><addtitle>Liver Int</addtitle><description>Background and Aims
Hepatocellular carcinoma (HCC) recurrence is common in patients treated with liver resection (LR). In this study, we aimed to evaluate the incidence and preoperative predictors of non‐transplantable recurrence in patients with single HCC ≤5 cm treated with frontline LR.
Methods
From the Italian Liver Cancer (ITA.LI.CA) database, 512 patients receiving frontline LR for single HCC ≤5 cm were retrieved. Incidence and predictors of recurrence beyond Milan criteria (MC) and up‐to‐seven criteria were compared between patients with HCC <4 and ≥4 cm.
Results
During a median follow‐up of 4.2 years, the overall recurrence rate was 55.9%. In the ≥4 cm group, a significantly higher proportion of patients recurred beyond MC at first recurrence (28.9% vs. 14.1%; p < 0.001) and overall (44.4% vs. 25.2%; p < 0.001). Similar results were found considering recurrence beyond up‐to‐seven criteria. Compared to those with larger tumours, patients with HCC <4 cm had a longer recurrence‐free survival and overall survival. HCC size ≥4 cm and high alpha‐fetoprotein (AFP) level at the time of LR were independent predictors of recurrence beyond MC (and up‐to‐seven criteria). In the subgroup of patients with available histologic information (n = 354), microvascular invasion and microsatellite lesions were identified as additional independent risk factors for non‐transplantable recurrence.
Conclusions
Despite the high recurrence rate, LR for single HCC ≤5 cm offers excellent long‐term survival. Non‐transplantable recurrence is predicted by HCC size and AFP levels, among pre‐operatively available variables. High‐risk patients could be considered for frontline LT or listed for transplantation even before recurrence.</description><subject>alpha-Fetoproteins</subject><subject>Carcinoma, Hepatocellular</subject><subject>Criteria</subject><subject>hepatectomy</subject><subject>Hepatectomy - methods</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Transplantation</subject><subject>Microvasculature</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>recurrence</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Subgroups</subject><subject>Survival</subject><subject>Transplantation</subject><subject>Tumors</subject><subject>tumour size</subject><issn>1478-3223</issn><issn>1478-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kc9qFTEUh4NYbK0ufAEJuKmL2-bPZGaylGJr4UJdqNshc-YMTclNricZy935CH1Gn8TUW7sQPJscwsfH7_Bj7I0Up7LOWfA_TqXppH3GjmTT9SuttHz-tCt9yF7mfCuEtNbIF-xQd53RphFHbPeZcPJQEmWeZh5T_PXzvpCLeRtcLG4MyAlhIcIIyH3kN7h1JQGGsARHHByBj2njeP32GEvmhdAVnPidLzd8phRL8BF5TYlUZRmh-BRfsYPZhYyvH99j9vXi45fzT6v19eXV-Yf1CnTf25U17aiMsn3XjlLL3kEzmQlEb6HVndZqFnODRgGAEr0yYEcYpXAKdTdr2epjdrL3bil9XzCXYePzQ3wXMS15UH1rW6lb01T03T_obVoo1nSVstoaIayq1Ps9BZRyJpyHLfmNo90gxfDQx1AvHf70Udm3j8Zl3OD0RP4toAJne-DOB9z93zSsr77tlb8BA4KXXw</recordid><startdate>202312</startdate><enddate>202312</enddate><creator>Pelizzaro, Filippo</creator><creator>Trevisani, Franco</creator><creator>Simeon, Vittorio</creator><creator>Vitale, Alessandro</creator><creator>Cillo, Umberto</creator><creator>Piscaglia, 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of non‐transplantable recurrence in hepatocellular carcinoma patients treated with frontline liver resection</title><author>Pelizzaro, Filippo ; Trevisani, Franco ; Simeon, Vittorio ; Vitale, Alessandro ; Cillo, Umberto ; Piscaglia, Fabio ; Missale, Gabriele ; Sangiovanni, Angelo ; Foschi, Francesco G. ; Cabibbo, Giuseppe ; Caturelli, Eugenio ; Di Marco, Maria ; Azzaroli, Francesco ; Brunetto, Maurizia R. ; Raimondo, Giovanni ; Vidili, Gianpaolo ; Guarino, Maria ; Gasbarrini, Antonio ; Campani, Claudia ; Svegliati‐Baroni, Gianluca ; Giannini, Edoardo G. ; Mega, Andrea ; Masotto, Alberto ; Rapaccini, Gian Ludovico ; Magalotti, Donatella ; Sacco, Rodolfo ; Nardone, Gerardo ; Farinati, Fabio ; Biselli, Maurizio ; Caraceni, Paolo ; Lani, Lorenzo ; Rampoldi, Davide ; Reggidori, Nicola ; Santi, Valentina ; Stefanini, Benedetta ; Granito, Alessandro ; Muratori, Luca ; Sansone, Vito ; Tovoli, Francesco ; Dajti, Elton ; Marasco, Giovanni ; Ravaioli, Federico ; Cappelli, Alberta ; Golfieri, Rita ; Mosconi, Cristina ; Renzulli, Matteo ; Pinto, Elisa ; Palano, Giorgio ; Kitenge, Maria Piera ; Bertellini, Federica ; Cela, Ester Marina ; Facciorusso, Antonio ; Pieri, Giulia ; Torres, Maria Corina Plaz ; Pasta, Andrea ; Matthaeis, Nicoletta ; Ponziani, Francesca Romana ; Ghittoni, Giorgia ; Lauria, Valentina ; Pelecca, Giorgio ; Chegai, Fabrizio ; Raso, Armando ; Bozzi, Alessio ; Biasini, Elisabetta ; Olivani, Andrea ; Inno, Alessandro ; Marchetti, Fabiana ; Celsa, Ciro ; Giuffrida, Paolo ; Giacchetto, Carmelo Marco ; Rancatore, Gabriele ; Grassini, Maria Vittoria ; Ciccia, Roberta ; Grova, Alessandro ; Salvato, Mauro ; Franzè, Maria Stella ; Saitta, Carlo ; Arru, Marco ; Sauchella, Assunta ; Serra, Maria Grazia ; Bevilacqua, Vittoria ; Borghi, Alberto ; Gardini, Andrea Casadei ; Conti, Fabio ; Dall’Aglio, Anna Chiara ; Ercolani, Giorgio ; Mirici, Federica ; Marra, Fabio ; Adotti, Valentina ; Rosi, Martina ; Coccoli, Pietro ; Malerba, Antonio ; Morisco, Filomena ; Cossiga, Valentina ; Capasso, Mario ; Romagnoli, Veronica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3889-956b2529876b1318ac4d5dc089c637332f0f4e52ccc20825c9bcb10a2e37f3163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>alpha-Fetoproteins</topic><topic>Carcinoma, Hepatocellular</topic><topic>Criteria</topic><topic>hepatectomy</topic><topic>Hepatectomy - methods</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Transplantation</topic><topic>Microvasculature</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>recurrence</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Subgroups</topic><topic>Survival</topic><topic>Transplantation</topic><topic>Tumors</topic><topic>tumour size</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pelizzaro, Filippo</creatorcontrib><creatorcontrib>Trevisani, Franco</creatorcontrib><creatorcontrib>Simeon, Vittorio</creatorcontrib><creatorcontrib>Vitale, Alessandro</creatorcontrib><creatorcontrib>Cillo, Umberto</creatorcontrib><creatorcontrib>Piscaglia, Fabio</creatorcontrib><creatorcontrib>Missale, Gabriele</creatorcontrib><creatorcontrib>Sangiovanni, Angelo</creatorcontrib><creatorcontrib>Foschi, Francesco G.</creatorcontrib><creatorcontrib>Cabibbo, Giuseppe</creatorcontrib><creatorcontrib>Caturelli, Eugenio</creatorcontrib><creatorcontrib>Di Marco, Maria</creatorcontrib><creatorcontrib>Azzaroli, Francesco</creatorcontrib><creatorcontrib>Brunetto, Maurizia R.</creatorcontrib><creatorcontrib>Raimondo, Giovanni</creatorcontrib><creatorcontrib>Vidili, Gianpaolo</creatorcontrib><creatorcontrib>Guarino, Maria</creatorcontrib><creatorcontrib>Gasbarrini, Antonio</creatorcontrib><creatorcontrib>Campani, Claudia</creatorcontrib><creatorcontrib>Svegliati‐Baroni, Gianluca</creatorcontrib><creatorcontrib>Giannini, Edoardo G.</creatorcontrib><creatorcontrib>Mega, Andrea</creatorcontrib><creatorcontrib>Masotto, Alberto</creatorcontrib><creatorcontrib>Rapaccini, Gian Ludovico</creatorcontrib><creatorcontrib>Magalotti, Donatella</creatorcontrib><creatorcontrib>Sacco, Rodolfo</creatorcontrib><creatorcontrib>Nardone, Gerardo</creatorcontrib><creatorcontrib>Farinati, Fabio</creatorcontrib><creatorcontrib>Biselli, Maurizio</creatorcontrib><creatorcontrib>Caraceni, Paolo</creatorcontrib><creatorcontrib>Lani, Lorenzo</creatorcontrib><creatorcontrib>Rampoldi, Davide</creatorcontrib><creatorcontrib>Reggidori, Nicola</creatorcontrib><creatorcontrib>Santi, Valentina</creatorcontrib><creatorcontrib>Stefanini, Benedetta</creatorcontrib><creatorcontrib>Granito, Alessandro</creatorcontrib><creatorcontrib>Muratori, Luca</creatorcontrib><creatorcontrib>Sansone, Vito</creatorcontrib><creatorcontrib>Tovoli, Francesco</creatorcontrib><creatorcontrib>Dajti, Elton</creatorcontrib><creatorcontrib>Marasco, Giovanni</creatorcontrib><creatorcontrib>Ravaioli, Federico</creatorcontrib><creatorcontrib>Cappelli, Alberta</creatorcontrib><creatorcontrib>Golfieri, Rita</creatorcontrib><creatorcontrib>Mosconi, Cristina</creatorcontrib><creatorcontrib>Renzulli, Matteo</creatorcontrib><creatorcontrib>Pinto, Elisa</creatorcontrib><creatorcontrib>Palano, Giorgio</creatorcontrib><creatorcontrib>Kitenge, Maria Piera</creatorcontrib><creatorcontrib>Bertellini, Federica</creatorcontrib><creatorcontrib>Cela, Ester Marina</creatorcontrib><creatorcontrib>Facciorusso, Antonio</creatorcontrib><creatorcontrib>Pieri, Giulia</creatorcontrib><creatorcontrib>Torres, Maria Corina Plaz</creatorcontrib><creatorcontrib>Pasta, Andrea</creatorcontrib><creatorcontrib>Matthaeis, Nicoletta</creatorcontrib><creatorcontrib>Ponziani, Francesca Romana</creatorcontrib><creatorcontrib>Ghittoni, Giorgia</creatorcontrib><creatorcontrib>Lauria, Valentina</creatorcontrib><creatorcontrib>Pelecca, Giorgio</creatorcontrib><creatorcontrib>Chegai, Fabrizio</creatorcontrib><creatorcontrib>Raso, Armando</creatorcontrib><creatorcontrib>Bozzi, Alessio</creatorcontrib><creatorcontrib>Biasini, Elisabetta</creatorcontrib><creatorcontrib>Olivani, Andrea</creatorcontrib><creatorcontrib>Inno, Alessandro</creatorcontrib><creatorcontrib>Marchetti, Fabiana</creatorcontrib><creatorcontrib>Celsa, Ciro</creatorcontrib><creatorcontrib>Giuffrida, Paolo</creatorcontrib><creatorcontrib>Giacchetto, Carmelo Marco</creatorcontrib><creatorcontrib>Rancatore, Gabriele</creatorcontrib><creatorcontrib>Grassini, Maria Vittoria</creatorcontrib><creatorcontrib>Ciccia, Roberta</creatorcontrib><creatorcontrib>Grova, Alessandro</creatorcontrib><creatorcontrib>Salvato, Mauro</creatorcontrib><creatorcontrib>Franzè, Maria Stella</creatorcontrib><creatorcontrib>Saitta, Carlo</creatorcontrib><creatorcontrib>Arru, Marco</creatorcontrib><creatorcontrib>Sauchella, Assunta</creatorcontrib><creatorcontrib>Serra, Maria Grazia</creatorcontrib><creatorcontrib>Bevilacqua, Vittoria</creatorcontrib><creatorcontrib>Borghi, Alberto</creatorcontrib><creatorcontrib>Gardini, Andrea Casadei</creatorcontrib><creatorcontrib>Conti, Fabio</creatorcontrib><creatorcontrib>Dall’Aglio, Anna Chiara</creatorcontrib><creatorcontrib>Ercolani, Giorgio</creatorcontrib><creatorcontrib>Mirici, Federica</creatorcontrib><creatorcontrib>Marra, Fabio</creatorcontrib><creatorcontrib>Adotti, Valentina</creatorcontrib><creatorcontrib>Rosi, Martina</creatorcontrib><creatorcontrib>Coccoli, Pietro</creatorcontrib><creatorcontrib>Malerba, Antonio</creatorcontrib><creatorcontrib>Morisco, Filomena</creatorcontrib><creatorcontrib>Cossiga, Valentina</creatorcontrib><creatorcontrib>Capasso, Mario</creatorcontrib><creatorcontrib>Romagnoli, Veronica</creatorcontrib><creatorcontrib>Italian Liver Cancer (ITA.LI.CA) group</creatorcontrib><creatorcontrib>for the Italian Liver Cancer (ITA.LI.CA) group</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Liver international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pelizzaro, Filippo</au><au>Trevisani, Franco</au><au>Simeon, Vittorio</au><au>Vitale, Alessandro</au><au>Cillo, Umberto</au><au>Piscaglia, Fabio</au><au>Missale, Gabriele</au><au>Sangiovanni, Angelo</au><au>Foschi, Francesco G.</au><au>Cabibbo, Giuseppe</au><au>Caturelli, Eugenio</au><au>Di Marco, Maria</au><au>Azzaroli, Francesco</au><au>Brunetto, Maurizia R.</au><au>Raimondo, Giovanni</au><au>Vidili, Gianpaolo</au><au>Guarino, Maria</au><au>Gasbarrini, Antonio</au><au>Campani, Claudia</au><au>Svegliati‐Baroni, Gianluca</au><au>Giannini, Edoardo G.</au><au>Mega, Andrea</au><au>Masotto, Alberto</au><au>Rapaccini, Gian Ludovico</au><au>Magalotti, Donatella</au><au>Sacco, Rodolfo</au><au>Nardone, Gerardo</au><au>Farinati, Fabio</au><au>Biselli, Maurizio</au><au>Caraceni, Paolo</au><au>Lani, Lorenzo</au><au>Rampoldi, Davide</au><au>Reggidori, Nicola</au><au>Santi, Valentina</au><au>Stefanini, Benedetta</au><au>Granito, Alessandro</au><au>Muratori, Luca</au><au>Sansone, Vito</au><au>Tovoli, Francesco</au><au>Dajti, Elton</au><au>Marasco, Giovanni</au><au>Ravaioli, Federico</au><au>Cappelli, Alberta</au><au>Golfieri, Rita</au><au>Mosconi, Cristina</au><au>Renzulli, Matteo</au><au>Pinto, Elisa</au><au>Palano, Giorgio</au><au>Kitenge, Maria Piera</au><au>Bertellini, Federica</au><au>Cela, Ester Marina</au><au>Facciorusso, Antonio</au><au>Pieri, Giulia</au><au>Torres, Maria Corina Plaz</au><au>Pasta, Andrea</au><au>Matthaeis, Nicoletta</au><au>Ponziani, Francesca Romana</au><au>Ghittoni, Giorgia</au><au>Lauria, Valentina</au><au>Pelecca, Giorgio</au><au>Chegai, Fabrizio</au><au>Raso, Armando</au><au>Bozzi, Alessio</au><au>Biasini, Elisabetta</au><au>Olivani, Andrea</au><au>Inno, Alessandro</au><au>Marchetti, Fabiana</au><au>Celsa, Ciro</au><au>Giuffrida, Paolo</au><au>Giacchetto, Carmelo Marco</au><au>Rancatore, Gabriele</au><au>Grassini, Maria Vittoria</au><au>Ciccia, Roberta</au><au>Grova, Alessandro</au><au>Salvato, Mauro</au><au>Franzè, Maria Stella</au><au>Saitta, Carlo</au><au>Arru, Marco</au><au>Sauchella, Assunta</au><au>Serra, Maria Grazia</au><au>Bevilacqua, Vittoria</au><au>Borghi, Alberto</au><au>Gardini, Andrea Casadei</au><au>Conti, Fabio</au><au>Dall’Aglio, Anna Chiara</au><au>Ercolani, Giorgio</au><au>Mirici, Federica</au><au>Marra, Fabio</au><au>Adotti, Valentina</au><au>Rosi, Martina</au><au>Coccoli, Pietro</au><au>Malerba, Antonio</au><au>Morisco, Filomena</au><au>Cossiga, Valentina</au><au>Capasso, Mario</au><au>Romagnoli, Veronica</au><aucorp>Italian Liver Cancer (ITA.LI.CA) group</aucorp><aucorp>for the Italian Liver Cancer (ITA.LI.CA) group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of non‐transplantable recurrence in hepatocellular carcinoma patients treated with frontline liver resection</atitle><jtitle>Liver international</jtitle><addtitle>Liver Int</addtitle><date>2023-12</date><risdate>2023</risdate><volume>43</volume><issue>12</issue><spage>2762</spage><epage>2775</epage><pages>2762-2775</pages><issn>1478-3223</issn><eissn>1478-3231</eissn><abstract>Background and Aims
Hepatocellular carcinoma (HCC) recurrence is common in patients treated with liver resection (LR). In this study, we aimed to evaluate the incidence and preoperative predictors of non‐transplantable recurrence in patients with single HCC ≤5 cm treated with frontline LR.
Methods
From the Italian Liver Cancer (ITA.LI.CA) database, 512 patients receiving frontline LR for single HCC ≤5 cm were retrieved. Incidence and predictors of recurrence beyond Milan criteria (MC) and up‐to‐seven criteria were compared between patients with HCC <4 and ≥4 cm.
Results
During a median follow‐up of 4.2 years, the overall recurrence rate was 55.9%. In the ≥4 cm group, a significantly higher proportion of patients recurred beyond MC at first recurrence (28.9% vs. 14.1%; p < 0.001) and overall (44.4% vs. 25.2%; p < 0.001). Similar results were found considering recurrence beyond up‐to‐seven criteria. Compared to those with larger tumours, patients with HCC <4 cm had a longer recurrence‐free survival and overall survival. HCC size ≥4 cm and high alpha‐fetoprotein (AFP) level at the time of LR were independent predictors of recurrence beyond MC (and up‐to‐seven criteria). In the subgroup of patients with available histologic information (n = 354), microvascular invasion and microsatellite lesions were identified as additional independent risk factors for non‐transplantable recurrence.
Conclusions
Despite the high recurrence rate, LR for single HCC ≤5 cm offers excellent long‐term survival. Non‐transplantable recurrence is predicted by HCC size and AFP levels, among pre‐operatively available variables. High‐risk patients could be considered for frontline LT or listed for transplantation even before recurrence.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37753540</pmid><doi>10.1111/liv.15719</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-4399-3359</orcidid><orcidid>https://orcid.org/0000-0002-8903-5829</orcidid><orcidid>https://orcid.org/0000-0001-8344-6523</orcidid><orcidid>https://orcid.org/0000-0003-3112-8587</orcidid><orcidid>https://orcid.org/0000-0002-0460-4122</orcidid><orcidid>https://orcid.org/0000-0002-6393-6995</orcidid><orcidid>https://orcid.org/0000-0003-0584-1442</orcidid><orcidid>https://orcid.org/0000-0003-4863-6924</orcidid><orcidid>https://orcid.org/0000-0001-8264-1845</orcidid><orcidid>https://orcid.org/0000-0002-9996-9385</orcidid><orcidid>https://orcid.org/0000-0001-8364-9152</orcidid><orcidid>https://orcid.org/0000-0003-3842-782X</orcidid><orcidid>https://orcid.org/0000-0001-6691-8701</orcidid><orcidid>https://orcid.org/0000-0002-2944-1374</orcidid><orcidid>https://orcid.org/0000-0002-4548-8308</orcidid><orcidid>https://orcid.org/0000-0001-8526-837X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1478-3223 |
| ispartof | Liver international, 2023-12, Vol.43 (12), p.2762-2775 |
| issn | 1478-3223 1478-3231 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2869613654 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | alpha-Fetoproteins Carcinoma, Hepatocellular Criteria hepatectomy Hepatectomy - methods Hepatocellular carcinoma Humans Liver Liver cancer Liver Neoplasms - pathology Liver Transplantation Microvasculature Neoplasm Recurrence, Local - pathology recurrence Retrospective Studies Risk factors Subgroups Survival Transplantation Tumors tumour size |
| title | Predictors of non‐transplantable recurrence in hepatocellular carcinoma patients treated with frontline liver resection |
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