Nanobubbles in water and wastewater treatment systems: Small bubbles making big difference

•A comprehensive review on the application of NBs in water and wastewater treatment.•NBs’ fundamental properties and their relevancy to water treatment.•Advancements in NB technology for water treatment processes beyond lab scale.•Existing controversies and inconsistencies in NBs literature.•Economic and environmental sustainability assessment of NB technology. Since the discovery of nanobubbles (NBs) in 1994, NBs have been attracting growing attention for their fascinating properties and have been studied for application in various environmental fields, including water and wastewater treatment. However, despite the intensive research efforts on NBs’ fundamental properties, especially in the past five years, controversies and disagreements in the published literature have hindered their practical implementation. So far, reviews of NB research have mainly focused on NBs’ role in specific treatment processes or general applications, highlighting proof-of-concept and success stories primarily at the laboratory scale. As such, there lacks a rigorous review that authenticates NBs’ potential beyond the bench scale. This review aims to provide a comprehensive and up-to-date analysis of the recent progress in NB research in the field of water and wastewater treatment at different scales, along with identifying and discussing the challenges and prospects of the technology. Herein, we systematically analyze (1) the fundamental properties of NBs and their relevancy to water treatment processes, (2) recent advances in NB applications for various treatment processes beyond the lab scale, including over 20 pilot and full-scale case studies, (3) a preliminary economic consideration of NB-integrated treatment processes (the case of NB-flotation), and (4) existing controversies in NBs research and the outlook for future research. This review is organized with the aim to provide readers with a step-by-step understanding of the subject matter while highlighting key insights as well as knowledge gaps requiring research to advance the use of NBs in the wastewater treatment industry. [Display omitted]