Antigenicity and infectivity characterisation of SARS-CoV-2 BA.2.86

By Sept 8, 2023, 95 sequences were detected, of which their early sequences originated from multiple countries, had no epidemiological relevance, and were found in individuals without a history of travel, suggesting the presence of underlying international transmission (appendix 1 p 7). [...]an expe...

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Veröffentlicht in:The Lancet infectious diseases 2023-11, Vol.23 (11), p.e457-e459
Hauptverfasser: Yang, Sijie, Yu, Yuanling, Jian, Fanchong, Song, Weiliang, Yisimayi, Ayijiang, Chen, Xiaosu, Xu, Yanli, Wang, Peng, Wang, Jing, Yu, Lingling, Niu, Xiao, Xiao, Tianhe, An, Ran, Wang, Yao, Gu, Qingqing, Shao, Fei, Jin, Ronghua, Shen, Zhongyang, Wang, Youchun, Cao, Yunlong
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Sprache:eng
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Zusammenfassung:By Sept 8, 2023, 95 sequences were detected, of which their early sequences originated from multiple countries, had no epidemiological relevance, and were found in individuals without a history of travel, suggesting the presence of underlying international transmission (appendix 1 p 7). [...]an experimental assessment of the antigenicity and infectivity of BA.2.86 is urgently needed. Saltation variants might have a compromised efficiency with regards to infecting host cells to gain a strong capability of evading neutralising antibodies elicited during the antibody–virus coevolution in long-term continuous host infection.8 Therefore, we next evaluated BA.2.86's cellular infectivity by testing the efficiency of its pseudovirus form to infect Vero cells and human ACE2-HEK293T cells (figure D; appendix 1 p 10).
ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(23)00573-X