Antigenicity and infectivity characterisation of SARS-CoV-2 BA.2.86
By Sept 8, 2023, 95 sequences were detected, of which their early sequences originated from multiple countries, had no epidemiological relevance, and were found in individuals without a history of travel, suggesting the presence of underlying international transmission (appendix 1 p 7). [...]an expe...
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Veröffentlicht in: | The Lancet infectious diseases 2023-11, Vol.23 (11), p.e457-e459 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | By Sept 8, 2023, 95 sequences were detected, of which their early sequences originated from multiple countries, had no epidemiological relevance, and were found in individuals without a history of travel, suggesting the presence of underlying international transmission (appendix 1 p 7). [...]an experimental assessment of the antigenicity and infectivity of BA.2.86 is urgently needed. Saltation variants might have a compromised efficiency with regards to infecting host cells to gain a strong capability of evading neutralising antibodies elicited during the antibody–virus coevolution in long-term continuous host infection.8 Therefore, we next evaluated BA.2.86's cellular infectivity by testing the efficiency of its pseudovirus form to infect Vero cells and human ACE2-HEK293T cells (figure D; appendix 1 p 10). |
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ISSN: | 1473-3099 1474-4457 |
DOI: | 10.1016/S1473-3099(23)00573-X |