Risk factors for preoperative and postoperative seizures in patients with glioblastoma according to the 2021 World Health Organization classification

•GBM-related preoperative seizures (PRS) are associated with non-occipital tumor location, younger age, and longer overall survival.•GBM-related postoperative seizures (POS) are associated with non-occipital tumor location and longer overall survival.•There was no association between the commonly tested tumor molecular markers and the occurrence of PRS or POS.•MGMT promotor methylation status was associated with longer overall survival in patients with GBM. To identify risk factors for developing glioblastoma (GBM) related preoperative (PRS) and postoperative seizures (POS). Also, we aimed to analyze the impact of PRS and POS on survival in a GBM cohort according to the revised 2021 WHO glioma classification. We performed a single-center retrospective cohort study of patients with GBM (according to the 2021 World Health Organization Classification) treated at Mayo Clinic Florida between January 2018 and July 2022. Seizures were stratified into preoperative seizures (PRS) and postoperative seizures (POS, >7 days after surgery). Associations between patients' characteristics and overall survival with PRS and POS were assessed. One hundred nineteen adults (mean =60.9 years), 49 (41.2 %) females, were identified. The rates of PRS and POS in the cohort were 35.3 % (n = 42) and 37.8 % (n = 45), respectively. Patients with PRS were younger (p = 0.035) and were likely to undergo intraoperative electrocorticography. The incidence of PRS (p = 0.049) and POS (p