White matter hyperintensity load mediates the relationship between age and cognition

To elucidate the relationship between age and cognitive decline, it is important to consider structural brain changes such as white matter hyperintensities (WMHs), which are common in older age and may affect behavior. Therefore, we aimed to investigate if WMH load is a mediator of the relationship...

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Veröffentlicht in:	Neurobiology of aging 2023-12, Vol.132, p.56-66
Hauptverfasser:	Busby, Natalie, Wilson, Sarah, Wilmskoetter, Janina, Newman-Norlund, Roger, Sayers, Sara, Newman-Norlund, Sarah, Roth, Rebecca, Rorden, Chris, Fridriksson, Julius, Bonilha, Leonardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Brain - diagnostic imaging Cognition Cognitive Dysfunction - etiology Cognitive Dysfunction - psychology Humans Magnetic Resonance Imaging Small vessel disease White Matter - diagnostic imaging White matter hyperintensities
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Zusammenfassung:	To elucidate the relationship between age and cognitive decline, it is important to consider structural brain changes such as white matter hyperintensities (WMHs), which are common in older age and may affect behavior. Therefore, we aimed to investigate if WMH load is a mediator of the relationship between age and cognitive decline. Healthy participants (N = 166, 20–80 years) completed the Montreal Cognitive Assessment (MoCA). WMHs were manually delineated on FLAIR scans. Mediation analysis was conducted to determine if WMH load mediates the relationship between age and cognition. Older age was associated with worse cognition (p
ISSN:	0197-4580 1558-1497 1558-1497
DOI:	10.1016/j.neurobiolaging.2023.08.007