Clinical and clonal characteristics of monoclonal immunoglobulin M-associated type I cryoglobulinaemia

Monoclonal immunoglobulin M-associated type I cryoglobulinaemia is poorly characterised. We screened 534 patients with monoclonal IgM disorders over a 9-year period and identified 134 patients with IgM type I cryoglobulins. Of these, 76% had Waldenström macroglobulinaemia (WM), 5% had other non-Hodg...

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Veröffentlicht in:	British journal of haematology 2024-01, Vol.204 (1), p.177-185
Hauptverfasser:	Khwaja, Jahanzaib, Vos, Josephine M I, Pluimers, Tessa E, Japzon, Nicole, Patel, Aisha, Salter, Simon, Kwakernaak, Arjan J, Gupta, Rajeev, Rismani, Ali, Kyriakou, Charalampia, Wechalekar, Ashutosh D, D'Sa, Shirley
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloidosis Antibodies, Monoclonal Benign monoclonal gammopathy Cold agglutinin disease Cryoglobulinemia - etiology Cryoglobulins Hematology Humans Immunoglobulin M Immunoglobulins Lymphoma, B-Cell Medical treatment Monoclonal Gammopathy of Undetermined Significance - diagnosis MyD88 protein Non-Hodgkin's lymphoma Paraproteins Patients Peripheral neuropathy Survival Waldenstrom Macroglobulinemia - pathology
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Zusammenfassung:	Monoclonal immunoglobulin M-associated type I cryoglobulinaemia is poorly characterised. We screened 534 patients with monoclonal IgM disorders over a 9-year period and identified 134 patients with IgM type I cryoglobulins. Of these, 76% had Waldenström macroglobulinaemia (WM), 5% had other non-Hodgkin lymphoma (NHL) and 19% had IgM monoclonal gammopathy of undetermined significance (MGUS). Clinically relevant IgM-associated disorders (including cold agglutinin disease [CAD], anti-MAG antibodies, amyloidosis and Schnitzler syndrome) coexisted in 31%, more frequently in MGUS versus WM/NHL (72% vs. 22%/29%, p
ISSN:	0007-1048 1365-2141
DOI:	10.1111/bjh.19112