A framework for intestinal barrier dysfunction in aging

A framework for intestinal barrier dysfunction in aging

The intestinal epithelium serves as a barrier that facilitates interaction between intrinsic and environmental factors. Aging is accompanied by the gradual deterioration of this barrier. We postulate that barrier dysfunction results from defects in epithelial membrane trafficking that exacerbate age...

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Veröffentlicht in:Nature aging 2023-10, Vol.3 (10), p.1172-1174
Hauptverfasser: Tatge, Lexus, Solano Fonseca, Rene, Douglas, Peter M
Format: Artikel
Sprache:eng
Schlagworte:
Age
Aging
Carbon
Cell adhesion & migration
Dyes
Gastrointestinal Diseases
Homeostasis
Humans
Intestinal Diseases
Kinases
Lipids
Metabolism
Permeability
Proteins
Recycling
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Zusammenfassung:The intestinal epithelium serves as a barrier that facilitates interaction between intrinsic and environmental factors. Aging is accompanied by the gradual deterioration of this barrier. We postulate that barrier dysfunction results from defects in epithelial membrane trafficking that exacerbate age-related metabolic imbalances. Herein, we integrate barrier integrity, protein homeostasis, membrane trafficking and intracellular lipid sensing into an age-determining mechanism.
ISSN:2662-8465
2662-8465
DOI:10.1038/s43587-023-00492-0