Lactobacillus fermentum attenuates the alveolar bone loss in ligature‐induced periodontitis in mice

Objective This study investigated the effects of Lactobacillus fermentum BELF11 on periodontitis in mice (LIP). Methods Sixty mice were randomly assigned to a control group (CTL), LIP/PBS group (LIP and PBS applied), or LIP/BELF11 group (LIP and L. fermentum BELF11 applied). For 14 days, PBS or L. f...

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Veröffentlicht in:	Oral diseases 2024-07, Vol.30 (5), p.3328-3335
Hauptverfasser:	Lee, Yuni, Jung, Bo Hyun, Yoo, Ki‐Yeon, Lim, Hye Ji, Shin, Kum‐Joo, Lee, Jae‐Kwan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveolar bone alveolar bone loss Alveolar Bone Loss - diagnostic imaging Alveolar Bone Loss - microbiology Alveolar Bone Loss - prevention & control Animals Bone density Bone loss Connective tissues cytokine Cytokines Cytokines - metabolism Cytotoxicity Gum disease Inflammation Lactobacillus fermentum Ligation Limosilactobacillus fermentum Lymphocytes T Male Mice Periodontitis Periodontitis - microbiology Periodontitis - pathology Periodontitis - therapy probiotics Probiotics - therapeutic use Random Allocation X‐ray microtomography
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Zusammenfassung:	Objective This study investigated the effects of Lactobacillus fermentum BELF11 on periodontitis in mice (LIP). Methods Sixty mice were randomly assigned to a control group (CTL), LIP/PBS group (LIP and PBS applied), or LIP/BELF11 group (LIP and L. fermentum BELF11 applied). For 14 days, PBS or L. fermentum BELF11 was applied twice daily to the mice in the LIP/PBS or LIP/BELF11 group, respectively. After 14 days, radiographic, histological, and pro‐inflammatory cytokine assessments were conducted. Results The LIP/PBS and LIP/BELF11 groups demonstrated greater alveolar bone loss than the CTL group (p
ISSN:	1354-523X 1601-0825 1601-0825
DOI:	10.1111/odi.14739