DPP9 Comes of Age: Highly Selective Inhibitors Promise New Therapeutic Opportunities
Dipeptidyl peptidase-like protein 9 (DPP9) is emerging as a promising drug target for the treatment of hematological diseases. Two novel DPP9 inhibitors with nanomolar affinity and unprecedented selectivity to DPP9 over DPP8 have been discovered, paving the way for future progress in DPP9-mediated t...
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| Veröffentlicht in: | Journal of medicinal chemistry 2023-09, Vol.66 (18), p.12715-12716 |
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| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Dipeptidyl peptidase-like protein 9 (DPP9) is emerging as a promising drug target for the treatment of hematological diseases. Two novel DPP9 inhibitors with nanomolar affinity and unprecedented selectivity to DPP9 over DPP8 have been discovered, paving the way for future progress in DPP9-mediated treatments. |
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| ISSN: | 0022-2623 1520-4804 |
| DOI: | 10.1021/acs.jmedchem.3c01631 |