Hemostatic considerations for gender affirming care

Gender dysphoria or gender incongruence is defined as “persons that are not satisfied with their designated gender” [1]. The awareness and evidence-based treatment options available to this population have grown immensely over the last two decades. Protocols now include an Endocrine Society Clinical Practice Guideline [1] as well as the World Professional Association of Transgender Health Standards of Care (WPATH SOC) [2]. Hematologic manifestations, most notably thrombosis, are one of the most recognized adverse reactions to the hormones used for gender-affirming care. Therefore, hematologists are frequently consulted prior to initiation of hormonal therapy to help guide safe treatment. This review will focus on the scientific evidence related to hemostatic considerations for various gender-affirming therapies and serve as a resource to assist in medical decision-making among providers and patients. •Create and provide inclusive, life-saving care for gender non-conforming individuals•Robust review of thromboembolic risk associated with gender-affirming hormone therapy•Therapy options: estrogen, testosterone, spironolactone, cyproterone acetate, surgery•Bleeding considerations in gender non-conforming patients