Non-invasive daily profiles of tissue adrenal steroids

In a new study, an ambulatory microdialysis system combined with ultrasensitive liquid chromatography-tandem mass spectrometry enabled the building of a 24-h high-resolution profile of adrenal steroids in the tissue by sampling interstitial fluid in 214 healthy volunteers. Daily and ultradian variat...

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Veröffentlicht in:	Nature reviews. Endocrinology 2023-11, Vol.19 (11), p.624-625
Hauptverfasser:	Bonnet-Serrano, Fidéline, Bertherat, Jérôme
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/776/1173 692/163/2743/1279 Aldosterone Automation Chromatography Circadian rhythm Cushing syndrome Endocrine disorders Endocrinology Hormones Liquid chromatography Mass spectrometry Mass spectroscopy Medicine Medicine & Public Health Metabolites Microdialysis News & Views news-and-views Physiology Plasma Scientific imaging Sleep Steroid hormones Steroids
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Beschreibung
Zusammenfassung:	In a new study, an ambulatory microdialysis system combined with ultrasensitive liquid chromatography-tandem mass spectrometry enabled the building of a 24-h high-resolution profile of adrenal steroids in the tissue by sampling interstitial fluid in 214 healthy volunteers. Daily and ultradian variations of eight free steroids, including cortisol and aldosterone, have been demonstrated, which opens new diagnostic perspectives for endocrine diseases.
ISSN:	1759-5029 1759-5037
DOI:	10.1038/s41574-023-00901-9