Pancreatic cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

•The guideline covers diagnosis, staging, risk assessment, treatment, disease monitoring and follow-up.•The multidisciplinary expert author group is from different institutions and countries in Europe, Asia and the USA.•Recommendations are based on available scientific data and the authors’ collective expert opinion.•ESMO-MCBS and ESCAT scores provide levels of evidence for treatment choices, including targeted therapies.•In clinical practice, all recommendations provided need to be discussed with patients in a shared decision-making approach.