ABCC2 brush‐border expression predicts outcome in papillary renal cell carcinoma: a multi‐institutional study of 254 cases

AimsPapillary renal cell carcinoma (PRCC) histologic subtyping is no longer recommended in the 2022 WHO classification. Currently, WHO/ISUP nucleolar grade is the only accepted prognostic histologic parameter for PRCC. ABCC2, a renal drug transporter, has been shown to significantly predict outcomes...

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Veröffentlicht in:	Histopathology 2023-12, Vol.83 (6), p.949-958
Hauptverfasser:	Castillo, Vincent Francis, Masoomian, Mehdi, Trpkov, Kiril, Downes, Michelle, Brimo, Fadi, van der Kwast, Theodorus, Yousef, George M, Zakhary, Abraam, Rotondo, Fabio, Saad, Gina, Nguyen, Vy‐nhan, Kidanewold, Wondwossen, Streutker, Catherine, Rowsell, Corwyn, Hamdani, Malek, Saleeb, Rola M
Format:	Artikel
Sprache:	eng
Schlagworte:	Gene expression Hybridization Kidney cancer Multivariate analysis Nucleoli Papillary renal cell carcinoma Survival analysis
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Zusammenfassung:	AimsPapillary renal cell carcinoma (PRCC) histologic subtyping is no longer recommended in the 2022 WHO classification. Currently, WHO/ISUP nucleolar grade is the only accepted prognostic histologic parameter for PRCC. ABCC2, a renal drug transporter, has been shown to significantly predict outcomes in PRCC. In this study we evaluated the prognostic significance of ABCC2 IHC staining patterns in a large, multi‐institutional PRCC cohort and assessed the association of these patterns with ABCC2 mRNA expression.Methods and resultsWe assessed 254 PRCCs for ABCC2 IHC reactivity patterns that were stratified into negative, cytoplasmic, brush‐border
ISSN:	0309-0167 1365-2559
DOI:	10.1111/his.15042