Cold blooded vertebrates help unveil a heat-dependent trigger

In a recent study, Hori and colleagues demonstrated that two specific residues located in the first ankyrin repeat of TRPV1 channels modulate the threshold for temperature activation. This study highlights the importance of considering natural diversity and comparative biology when approaching biophysical questions. In a recent study, Hori and colleagues demonstrated that two specific residues located in the first ankyrin repeat of TRPV1 channels modulate the threshold for temperature activation. This study highlights the importance of considering natural diversity and comparative biology when approaching biophysical questions.