Advancing multiplexed imaging for enhanced tissue complexity analysis

Advancing multiplexed imaging for enhanced tissue complexity analysis

Multiplexed spatial immunophenotyping has advanced our understanding of tissues in the context of homeostasis and disease. Two studies now provide additional tools to overcome challenges with multiplexed imaging: one procedure amplifies the detection of low-abundance antigens by integrating SABER an...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature methods 2023-09, Vol.20 (9), p.1280-1281
Hauptverfasser: Ijsselsteijn, Marieke E., de Miranda, Noel F. C. C.
Format: Artikel
Sprache:eng
Schlagworte:
631/1647/245
631/67/2321
631/67/327
Antibodies
Antigens
Bioinformatics
Biological Microscopy
Biological Techniques
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Homeostasis
Laboratories
Life Sciences
Medical imaging
Methods
Multiplexing
News & Views
news-and-views
Nondestructive testing
Proteins
Proteomics
Spatial analysis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Multiplexed spatial immunophenotyping has advanced our understanding of tissues in the context of homeostasis and disease. Two studies now provide additional tools to overcome challenges with multiplexed imaging: one procedure amplifies the detection of low-abundance antigens by integrating SABER and IMC technologies, and the other is an X-ray-based method that enables the non-destructive multiplexed detection of antigens in tissues at scalable resolution and speed.
ISSN:1548-7091
1548-7105
DOI:10.1038/s41592-023-01935-7