Total neoadjuvant therapy for locally advanced rectal cancer: a narrative review

Locally advanced rectal cancer has traditionally been treated with chemoradiotherapy (CRT) followed by surgery and adjuvant chemotherapy. However, a new strategy, total neoadjuvant therapy, involves the administration of CRT and neoadjuvant chemotherapy with the aim of eradicating micrometastases earlier and achieving greater control of the disease. The use of total neoadjuvant therapy has shown higher rates of pathological complete response and resectability compared with CRT, including improved survival. Nevertheless, distant relapse is the main cause of morbidity and mortality in locally advanced rectal cancer. To address this, new biomarkers are being developed to predict disease response. Exciting breakthrough and results in rectal cancer treatment with total neoadjuvant therapy. Chemoradiotherapy and presurgery chemotherapy for better disease control. Higher complete response rates and improved survival. Ongoing search for new biomarkers. #FutureOncology