Lymph node metastases in young patients with gastrointestinal stromal tumor: A nationwide analysis

Lymph node metastases in young patients with gastrointestinal stromal tumor: A nationwide analysis

BackgroundChildren, adolescents, and young adults (CAYA) (age ≤39 years) with GIST have high rates of LNM, but their clinical relevance is undefined. This study analyzed the impact of LNM on overall survival (OS) for CAYA with GIST.MethodsThe National Cancer Database was queried for patients with re...

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Veröffentlicht in:Journal of surgical oncology 2023-12, Vol.128 (8), p.1268-1277
Hauptverfasser: Fleming, Andrew M., Herb, Joshua, Stiles, Zachary E., Burkbauer, Laura, Dickson, Paxton V., Glazer, Evan S., Shibata, David, Murphy, Andrew J., Davidoff, Andrew M., Gleeson, Elizabeth, Kim, Hong J., Meyers, Michael O., Stitzenberg, Karyn, Ollila, David W., Deneve, Jeremiah L.
Format: Artikel
Sprache:eng
Schlagworte:
Gastrointestinal cancer
Lymphatic system
Older people
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Zusammenfassung:BackgroundChildren, adolescents, and young adults (CAYA) (age ≤39 years) with GIST have high rates of LNM, but their clinical relevance is undefined. This study analyzed the impact of LNM on overall survival (OS) for CAYA with GIST.MethodsThe National Cancer Database was queried for patients with resected GIST and pathologic nodal staging data from 2004—2019. Factors associated with LNM were identified. Survival was assessed stratified by presence of LNM.ResultsOf 4420 patients with GIST, 238 were CAYA (5.4%). When compared to older adults, CAYA more often had small intestine primaries (51.8% vs. 36.6%, p 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.27431