Clonal Hematopoiesis Has Prognostic Value in Dilated Cardiomyopathy Independent of Age and Clone Size

Clonal Hematopoiesis Has Prognostic Value in Dilated Cardiomyopathy Independent of Age and Clone Size

Clonal hematopoiesis (CH) gives rise to mutated leukocyte clones that induce cardiovascular inflammation and thereby impact the disease course in atherosclerosis and ischemic heart failure. CH of indeterminate potential refers to a variant allele frequency (VAF) (a marker for clone size) in blood of...

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Veröffentlicht in:JACC. Heart failure 2024-05, Vol.12 (5), p.905-914
Hauptverfasser: Sikking, Maurits A., Stroeks, Sophie L.V.M., Henkens, Michiel T.H.M., Raafs, Anne G., Cossins, Benjamin, van Deuren, Rosanne C., Steehouwer, Marlies, Riksen, Niels P., van den Wijngaard, Arthur, Brunner, Han G., Hoischen, Alexander, Verdonschot, Job A.J., Heymans, Stephane R.B.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Age Factors
Aged
Cardiomyopathy, Dilated - genetics
Cardiomyopathy, Dilated - physiopathology
clonal hematopoiesis
Clonal Hematopoiesis - genetics
dilated cardiomyopathy
Female
Gene Frequency
heart failure
Humans
Male
Middle Aged
Mutation
Prognosis
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Zusammenfassung:Clonal hematopoiesis (CH) gives rise to mutated leukocyte clones that induce cardiovascular inflammation and thereby impact the disease course in atherosclerosis and ischemic heart failure. CH of indeterminate potential refers to a variant allele frequency (VAF) (a marker for clone size) in blood of ≥2%. The impact of CH clones—including small clone sizes (VAF 
ISSN:2213-1779
2213-1787
DOI:10.1016/j.jchf.2023.06.037