Design and Synthesis of Artificial Nucleobases for Sequence‐Selective DNA Recognition within the Major Groove

We present the design and synthesis of artificial specific nucleobases, each one recognizing a single base pair within the major groove of duplex DNA. Computational calculations indicate that PNAs modified with these nucleobases enable the formation of highly stable triple helices with no sequence r...

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Veröffentlicht in:	Chemistry, an Asian journal an Asian journal, 2023-10, Vol.18 (19), p.e202300637-e202300637
Hauptverfasser:	Alavijeh, Nahid S., Serrano, Alvaro, Peters, Max S., Wölper, Christoph, Schrader, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Grooves Helices Hydrogen bonding NMR Nuclear magnetic resonance Synthesis Titration
Online-Zugang:	Volltext
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