Divergent neurodevelopmental profiles of very-low-birth-weight infants
Background Advanced perinatal medicine has decreased the mortality rate of preterm infants. Long-term neurodevelopmental outcomes of very-low-birth-weight infants (VLBWIs) remain to be investigated. Methods Participants were 124 VLBWIs who had in-hospital birth from 2007 to 2015. Perinatal informati...
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| Veröffentlicht in: | Pediatric research 2024-01, Vol.95 (1), p.233-240 |
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| creator | Ogata, Reina Watanabe, Kyoko Chong, Pin Fee Okamoto, Jun Sakemi, Yoshihiro Nakashima, Toshinori Ohno, Takuro Nomiyama, Hiroyuki Sonoda, Yuri Ichimiya, Yuko Inoue, Hirosuke Ochiai, Masayuki Yamashita, Hironori Sakai, Yasunari Ohga, Shouichi |
| description | Background
Advanced perinatal medicine has decreased the mortality rate of preterm infants. Long-term neurodevelopmental outcomes of very-low-birth-weight infants (VLBWIs) remain to be investigated.
Methods
Participants were 124 VLBWIs who had in-hospital birth from 2007 to 2015. Perinatal information, developmental or intelligence quotient (DQ/IQ), and neurological comorbidities at ages 3 and 6 years were analyzed.
Results
Fifty-eight (47%) VLBWIs received neurodevelopmental assessments at ages 3 and 6 years. Among them, 15 (26%) showed DQ/IQ |
| doi_str_mv | 10.1038/s41390-023-02778-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2857846589</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2916529482</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-5fa0dcb07f8c6da1e51a944c5162534869ddf39b2ad2444d2e20e73e21ddcdaf3</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMotlb_gAdZ8OIlms_d5ChqVSh40XNIN5N2y3a3Jrst_fdGWxU8eBgGJs-8GR6Ezim5poSrmygo1wQTxlMVhcKbAzSkkqeREMUhGhLCKeZaqwE6iXFBCBVSiWM04EXOcsrIEI3vqzWEGTRd1kAfWgdrqNvVMg1sna1C66saYtb6LGFbXLcbPK1CN8cbqGbzLqsab5sunqIjb-sIZ_s-Qm_jh9e7Jzx5eXy-u53gkheyw9Jb4sopKbwqc2cpSGq1EKWkOZNcqFw757meMuuYEMIxYAQKDow6Vzrr-Qhd7XLTZe89xM4sq1hCXdsG2j4apmShRC6VTujlH3TR9qFJ1xmmaS6ZFooliu2oMrQxBvBmFaqlDVtDifm0bHaWTbJsviybTVq62Ef30yW4n5VvrQngOyCmp2YG4ffvf2I_AF7yiRI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2916529482</pqid></control><display><type>article</type><title>Divergent neurodevelopmental profiles of very-low-birth-weight infants</title><source>Springer Nature - Complete Springer Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Ogata, Reina ; Watanabe, Kyoko ; Chong, Pin Fee ; Okamoto, Jun ; Sakemi, Yoshihiro ; Nakashima, Toshinori ; Ohno, Takuro ; Nomiyama, Hiroyuki ; Sonoda, Yuri ; Ichimiya, Yuko ; Inoue, Hirosuke ; Ochiai, Masayuki ; Yamashita, Hironori ; Sakai, Yasunari ; Ohga, Shouichi</creator><creatorcontrib>Ogata, Reina ; Watanabe, Kyoko ; Chong, Pin Fee ; Okamoto, Jun ; Sakemi, Yoshihiro ; Nakashima, Toshinori ; Ohno, Takuro ; Nomiyama, Hiroyuki ; Sonoda, Yuri ; Ichimiya, Yuko ; Inoue, Hirosuke ; Ochiai, Masayuki ; Yamashita, Hironori ; Sakai, Yasunari ; Ohga, Shouichi</creatorcontrib><description>Background
Advanced perinatal medicine has decreased the mortality rate of preterm infants. Long-term neurodevelopmental outcomes of very-low-birth-weight infants (VLBWIs) remain to be investigated.
Methods
Participants were 124 VLBWIs who had in-hospital birth from 2007 to 2015. Perinatal information, developmental or intelligence quotient (DQ/IQ), and neurological comorbidities at ages 3 and 6 years were analyzed.
Results
Fifty-eight (47%) VLBWIs received neurodevelopmental assessments at ages 3 and 6 years. Among them, 15 (26%) showed DQ/IQ <75 at age 6 years. From age 3 to 6 years, 21 (36%) patients showed a decrease (≤–10), while 5 (9%) showed an increase (≥+10) in DQ/IQ scores. Eight (17%) with autism spectrum disorder or attention-deficit hyperactivity disorder (ASD/ADHD) showed split courses of DQ/IQ, including two with ≤–10 and one with +31 to their scores. On the other hand, all 7 VLBWIs with cerebral palsy showed DQ ≤35 at these ages. Magnetic resonance imaging detected severe brain lesions in 7 (47%) of those with DQ <75 and 1 (18%) with ASD/ADHD.
Conclusions
VLBWIs show a broad spectrum of neurodevelopmental outcomes after 6 years. These divergent profiles also indicate that different risks contribute to the development of ASD/ADHD from those of cerebral palsy and epilepsy in VLBWIs.
Impact
Very-low-birth-weight infants (VLBWIs) show divergent neurodevelopmental outcomes from age 3 to 6 years.
A deep longitudinal study depicts the dynamic change in neurodevelopmental profiles of VLBWIs from age 3 to 6 years.
Perinatal brain injury is associated with developmental delay, cerebral palsy and epilepsy, but not with ASD or ADHD at age 6 years.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/s41390-023-02778-w</identifier><identifier>PMID: 37626120</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Attention deficit hyperactivity disorder ; Autism ; Birth weight ; Cerebral palsy ; Clinical Research Article ; Epilepsy ; Medicine ; Medicine & Public Health ; Pediatric Surgery ; Pediatrics</subject><ispartof>Pediatric research, 2024-01, Vol.95 (1), p.233-240</ispartof><rights>The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-5fa0dcb07f8c6da1e51a944c5162534869ddf39b2ad2444d2e20e73e21ddcdaf3</citedby><cites>FETCH-LOGICAL-c375t-5fa0dcb07f8c6da1e51a944c5162534869ddf39b2ad2444d2e20e73e21ddcdaf3</cites><orcidid>0000-0002-5747-8692</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41390-023-02778-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41390-023-02778-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37626120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogata, Reina</creatorcontrib><creatorcontrib>Watanabe, Kyoko</creatorcontrib><creatorcontrib>Chong, Pin Fee</creatorcontrib><creatorcontrib>Okamoto, Jun</creatorcontrib><creatorcontrib>Sakemi, Yoshihiro</creatorcontrib><creatorcontrib>Nakashima, Toshinori</creatorcontrib><creatorcontrib>Ohno, Takuro</creatorcontrib><creatorcontrib>Nomiyama, Hiroyuki</creatorcontrib><creatorcontrib>Sonoda, Yuri</creatorcontrib><creatorcontrib>Ichimiya, Yuko</creatorcontrib><creatorcontrib>Inoue, Hirosuke</creatorcontrib><creatorcontrib>Ochiai, Masayuki</creatorcontrib><creatorcontrib>Yamashita, Hironori</creatorcontrib><creatorcontrib>Sakai, Yasunari</creatorcontrib><creatorcontrib>Ohga, Shouichi</creatorcontrib><title>Divergent neurodevelopmental profiles of very-low-birth-weight infants</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
Advanced perinatal medicine has decreased the mortality rate of preterm infants. Long-term neurodevelopmental outcomes of very-low-birth-weight infants (VLBWIs) remain to be investigated.
Methods
Participants were 124 VLBWIs who had in-hospital birth from 2007 to 2015. Perinatal information, developmental or intelligence quotient (DQ/IQ), and neurological comorbidities at ages 3 and 6 years were analyzed.
Results
Fifty-eight (47%) VLBWIs received neurodevelopmental assessments at ages 3 and 6 years. Among them, 15 (26%) showed DQ/IQ <75 at age 6 years. From age 3 to 6 years, 21 (36%) patients showed a decrease (≤–10), while 5 (9%) showed an increase (≥+10) in DQ/IQ scores. Eight (17%) with autism spectrum disorder or attention-deficit hyperactivity disorder (ASD/ADHD) showed split courses of DQ/IQ, including two with ≤–10 and one with +31 to their scores. On the other hand, all 7 VLBWIs with cerebral palsy showed DQ ≤35 at these ages. Magnetic resonance imaging detected severe brain lesions in 7 (47%) of those with DQ <75 and 1 (18%) with ASD/ADHD.
Conclusions
VLBWIs show a broad spectrum of neurodevelopmental outcomes after 6 years. These divergent profiles also indicate that different risks contribute to the development of ASD/ADHD from those of cerebral palsy and epilepsy in VLBWIs.
Impact
Very-low-birth-weight infants (VLBWIs) show divergent neurodevelopmental outcomes from age 3 to 6 years.
A deep longitudinal study depicts the dynamic change in neurodevelopmental profiles of VLBWIs from age 3 to 6 years.
Perinatal brain injury is associated with developmental delay, cerebral palsy and epilepsy, but not with ASD or ADHD at age 6 years.</description><subject>Attention deficit hyperactivity disorder</subject><subject>Autism</subject><subject>Birth weight</subject><subject>Cerebral palsy</subject><subject>Clinical Research Article</subject><subject>Epilepsy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kE1LAzEQhoMotlb_gAdZ8OIlms_d5ChqVSh40XNIN5N2y3a3Jrst_fdGWxU8eBgGJs-8GR6Ezim5poSrmygo1wQTxlMVhcKbAzSkkqeREMUhGhLCKeZaqwE6iXFBCBVSiWM04EXOcsrIEI3vqzWEGTRd1kAfWgdrqNvVMg1sna1C66saYtb6LGFbXLcbPK1CN8cbqGbzLqsab5sunqIjb-sIZ_s-Qm_jh9e7Jzx5eXy-u53gkheyw9Jb4sopKbwqc2cpSGq1EKWkOZNcqFw757meMuuYEMIxYAQKDow6Vzrr-Qhd7XLTZe89xM4sq1hCXdsG2j4apmShRC6VTujlH3TR9qFJ1xmmaS6ZFooliu2oMrQxBvBmFaqlDVtDifm0bHaWTbJsviybTVq62Ef30yW4n5VvrQngOyCmp2YG4ffvf2I_AF7yiRI</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Ogata, Reina</creator><creator>Watanabe, Kyoko</creator><creator>Chong, Pin Fee</creator><creator>Okamoto, Jun</creator><creator>Sakemi, Yoshihiro</creator><creator>Nakashima, Toshinori</creator><creator>Ohno, Takuro</creator><creator>Nomiyama, Hiroyuki</creator><creator>Sonoda, Yuri</creator><creator>Ichimiya, Yuko</creator><creator>Inoue, Hirosuke</creator><creator>Ochiai, Masayuki</creator><creator>Yamashita, Hironori</creator><creator>Sakai, Yasunari</creator><creator>Ohga, Shouichi</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5747-8692</orcidid></search><sort><creationdate>20240101</creationdate><title>Divergent neurodevelopmental profiles of very-low-birth-weight infants</title><author>Ogata, Reina ; Watanabe, Kyoko ; Chong, Pin Fee ; Okamoto, Jun ; Sakemi, Yoshihiro ; Nakashima, Toshinori ; Ohno, Takuro ; Nomiyama, Hiroyuki ; Sonoda, Yuri ; Ichimiya, Yuko ; Inoue, Hirosuke ; Ochiai, Masayuki ; Yamashita, Hironori ; Sakai, Yasunari ; Ohga, Shouichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-5fa0dcb07f8c6da1e51a944c5162534869ddf39b2ad2444d2e20e73e21ddcdaf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Attention deficit hyperactivity disorder</topic><topic>Autism</topic><topic>Birth weight</topic><topic>Cerebral palsy</topic><topic>Clinical Research Article</topic><topic>Epilepsy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogata, Reina</creatorcontrib><creatorcontrib>Watanabe, Kyoko</creatorcontrib><creatorcontrib>Chong, Pin Fee</creatorcontrib><creatorcontrib>Okamoto, Jun</creatorcontrib><creatorcontrib>Sakemi, Yoshihiro</creatorcontrib><creatorcontrib>Nakashima, Toshinori</creatorcontrib><creatorcontrib>Ohno, Takuro</creatorcontrib><creatorcontrib>Nomiyama, Hiroyuki</creatorcontrib><creatorcontrib>Sonoda, Yuri</creatorcontrib><creatorcontrib>Ichimiya, Yuko</creatorcontrib><creatorcontrib>Inoue, Hirosuke</creatorcontrib><creatorcontrib>Ochiai, Masayuki</creatorcontrib><creatorcontrib>Yamashita, Hironori</creatorcontrib><creatorcontrib>Sakai, Yasunari</creatorcontrib><creatorcontrib>Ohga, Shouichi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogata, Reina</au><au>Watanabe, Kyoko</au><au>Chong, Pin Fee</au><au>Okamoto, Jun</au><au>Sakemi, Yoshihiro</au><au>Nakashima, Toshinori</au><au>Ohno, Takuro</au><au>Nomiyama, Hiroyuki</au><au>Sonoda, Yuri</au><au>Ichimiya, Yuko</au><au>Inoue, Hirosuke</au><au>Ochiai, Masayuki</au><au>Yamashita, Hironori</au><au>Sakai, Yasunari</au><au>Ohga, Shouichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Divergent neurodevelopmental profiles of very-low-birth-weight infants</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>95</volume><issue>1</issue><spage>233</spage><epage>240</epage><pages>233-240</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background
Advanced perinatal medicine has decreased the mortality rate of preterm infants. Long-term neurodevelopmental outcomes of very-low-birth-weight infants (VLBWIs) remain to be investigated.
Methods
Participants were 124 VLBWIs who had in-hospital birth from 2007 to 2015. Perinatal information, developmental or intelligence quotient (DQ/IQ), and neurological comorbidities at ages 3 and 6 years were analyzed.
Results
Fifty-eight (47%) VLBWIs received neurodevelopmental assessments at ages 3 and 6 years. Among them, 15 (26%) showed DQ/IQ <75 at age 6 years. From age 3 to 6 years, 21 (36%) patients showed a decrease (≤–10), while 5 (9%) showed an increase (≥+10) in DQ/IQ scores. Eight (17%) with autism spectrum disorder or attention-deficit hyperactivity disorder (ASD/ADHD) showed split courses of DQ/IQ, including two with ≤–10 and one with +31 to their scores. On the other hand, all 7 VLBWIs with cerebral palsy showed DQ ≤35 at these ages. Magnetic resonance imaging detected severe brain lesions in 7 (47%) of those with DQ <75 and 1 (18%) with ASD/ADHD.
Conclusions
VLBWIs show a broad spectrum of neurodevelopmental outcomes after 6 years. These divergent profiles also indicate that different risks contribute to the development of ASD/ADHD from those of cerebral palsy and epilepsy in VLBWIs.
Impact
Very-low-birth-weight infants (VLBWIs) show divergent neurodevelopmental outcomes from age 3 to 6 years.
A deep longitudinal study depicts the dynamic change in neurodevelopmental profiles of VLBWIs from age 3 to 6 years.
Perinatal brain injury is associated with developmental delay, cerebral palsy and epilepsy, but not with ASD or ADHD at age 6 years.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>37626120</pmid><doi>10.1038/s41390-023-02778-w</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5747-8692</orcidid></addata></record> |
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| ispartof | Pediatric research, 2024-01, Vol.95 (1), p.233-240 |
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| language | eng |
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| source | Springer Nature - Complete Springer Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Attention deficit hyperactivity disorder Autism Birth weight Cerebral palsy Clinical Research Article Epilepsy Medicine Medicine & Public Health Pediatric Surgery Pediatrics |
| title | Divergent neurodevelopmental profiles of very-low-birth-weight infants |
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