Evolution of Partial Resistance to Artemisinins in Malaria Parasites in Uganda

Artemisinins are the backbone of combination therapies for malaria. In a study of malaria in Uganda, investigators found multifocal emergence and spread of Plasmodium falciparum with partial resistance to artemisinins.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2023-08, Vol.389 (8), p.722-732
Hauptverfasser:	Conrad, Melissa D., Asua, Victor, Garg, Shreeya, Giesbrecht, David, Niaré, Karamoko, Smith, Sawyer, Namuganga, Jane F., Katairo, Thomas, Legac, Jennifer, Crudale, Rebecca M., Tumwebaze, Patrick K., Nsobya, Samuel L., Cooper, Roland A., Kamya, Moses R., Dorsey, Grant, Bailey, Jeffrey A., Rosenthal, Philip J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Artemisinin Artemisinins - pharmacology Artemisinins - therapeutic use Benchmarking Drug Resistance - genetics Genetic analysis Global Health Humans Infectious Disease Infectious Disease General Kelch protein Malaria Malaria - drug therapy Malaria - genetics Malaria - parasitology Mutation Parasites Parasites - drug effects Parasites - genetics Parasitic Infections Plasmodium falciparum Protozoan Proteins - genetics Software Surveillance Uganda - epidemiology
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Beschreibung
Zusammenfassung:	Artemisinins are the backbone of combination therapies for malaria. In a study of malaria in Uganda, investigators found multifocal emergence and spread of Plasmodium falciparum with partial resistance to artemisinins.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2211803