Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia

Here we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. Although STRN3-RARA leukemia quickly relapses after all-trans retinoic acid treatment, it can be restrained by cepharanthine.

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Bibliographische Detailangaben
Veröffentlicht in:	Blood 2023-10, Vol.142 (17), p.1494-1499
Hauptverfasser:	Zhang, Qi, Li, He, Chen, Xuelan, Gu, Fan, Zhang, Lanxin, Zhang, Lu, Chen, Tong, Chen, Qiang, Meng, Wentong, Wu, Yu, Chang, Hong, Liu, Ting, Chen, Chong, Ma, Hongbing, Liu, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - genetics Mice Oncogene Proteins, Fusion - genetics Tretinoin - therapeutic use
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Beschreibung
Zusammenfassung:	Here we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. Although STRN3-RARA leukemia quickly relapses after all-trans retinoic acid treatment, it can be restrained by cepharanthine.
ISSN:	0006-4971 1528-0020
DOI:	10.1182/blood.2023020619