Kevin Lafferty and the lymphocyte costimulator: theory and practice in Canberra

Kevin Lafferty and the lymphocyte costimulator: theory and practice in Canberra

Between 1969 and 1983 the lab of Kevin Lafferty in Canberra developed the concept of the T‐cell “costimulator,” an essential second signal for activation. A great deal of the work appeared in this journal before it was known as Immunology & Cell Biology (ICB). As part of the 100‐year anniversary...

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Veröffentlicht in:Immunology and cell biology 2023-09, Vol.101 (8), p.678-683
1. Verfasser: Hodgkin, Philip D
Format: Artikel
Sprache:eng
Schlagworte:
Adaptive immunity
antigen presentation
cellular immunity
clonal selection
Costimulator
Lymphocytes
transplant immunology
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Zusammenfassung:Between 1969 and 1983 the lab of Kevin Lafferty in Canberra developed the concept of the T‐cell “costimulator,” an essential second signal for activation. A great deal of the work appeared in this journal before it was known as Immunology & Cell Biology (ICB). As part of the 100‐year anniversary of the journal, I offer a personal reflection on Kevin's legacy and impact. Between 1969 and 1983 the lab of Kevin Lafferty in Canberra developed the concept of the T‐cell “costimulator,” an essential second signal for activation. A great deal of the work appeared in this journal before it was known as Immunology & Cell Biology (ICB). As part of the 100‐year anniversary of the journal, I offer a personal reflection on Kevin's legacy and impact.
ISSN:0818-9641
1440-1711
DOI:10.1111/imcb.12683