Harnessing the dual antimicrobial mode of action with a lipophilic Mn( ii ) complex using the principle of the Irving–Williams Series to completely eradicate Staphylococcus aurous

Harnessing the dual antimicrobial mode of action with a lipophilic Mn( ii ) complex using the principle of the Irving–Williams Series to completely eradicate Staphylococcus aurous

The judicious selection of 5,7-dibromo-2-methy-8-quinolinol (BQ) as a Mn( ii ) ionophore results in the synthesis of Mn(BQ) 2 (DMSO) 2 ·DMSO (1), a potent metalloantibiotic with a dual antimicrobial mode of action against four different strains of Staphylococcus aurous (SA) bacteria (MIC = 0.625 μg...

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Veröffentlicht in:Dalton transactions : an international journal of inorganic chemistry 2023-09, Vol.52 (35), p.12203-12207
Hauptverfasser: Mudarmah, Khalil, Bagale, Bijaya, Chen, Guanyu, Krause, Jeanette A., Mighion, Jeffrey D., Huang, Songping D.
Format: Artikel
Sprache:eng
Schlagworte:
Bacteria
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Zusammenfassung:The judicious selection of 5,7-dibromo-2-methy-8-quinolinol (BQ) as a Mn( ii ) ionophore results in the synthesis of Mn(BQ) 2 (DMSO) 2 ·DMSO (1), a potent metalloantibiotic with a dual antimicrobial mode of action against four different strains of Staphylococcus aurous (SA) bacteria (MIC = 0.625 μg mL −1 ). Additionally, 1 can overcome ciprofloxacin-resistance in methicillin-resistant SA bacteria.
ISSN:1477-9226
1477-9234
DOI:10.1039/d3dt01904g