Obesity, Glycemic Traits, Lifestyle Factors, and Risk of Facial Aging: A Mendelian Randomization Study in 423,999 Participants

Obesity, Glycemic Traits, Lifestyle Factors, and Risk of Facial Aging: A Mendelian Randomization Study in 423,999 Participants

Background Several recent observational studies have associated obesity, lifestyle factors (smoking, sleep duration, and alcohol drinking), and glycemic traits with facial aging. However, whether this relationship is causal due to confounding and reverse causation is yet to be substantiated. Aims We...

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Veröffentlicht in:Aesthetic plastic surgery 2024-03, Vol.48 (5), p.1005-1015
Hauptverfasser: Liu, Xuan-jun, Sultan, Muhammad Tipu, Li, Guang-shuai
Format: Artikel
Sprache:eng
Schlagworte:
Aging
Animals
Body mass index
Evidence-based medicine
Genome-Wide Association Study
Genomes
Humans
Life Style
Medicine
Medicine & Public Health
Mendelian Randomization Analysis
Obesity
Obesity - epidemiology
Obesity - genetics
Original Articles
Otorhinolaryngology
Plastic Surgery
Smoking
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Zusammenfassung:Background Several recent observational studies have associated obesity, lifestyle factors (smoking, sleep duration, and alcohol drinking), and glycemic traits with facial aging. However, whether this relationship is causal due to confounding and reverse causation is yet to be substantiated. Aims We aimed to assess these relationships using Mendelian randomization (MR). Methods For the instrumental variables, this paper selected independent single nucleotide polymorphisms (SNPs) linked to the exposures at a genome-wide state ( P  
ISSN:0364-216X
1432-5241
1432-5241
DOI:10.1007/s00266-023-03551-4