Bone Homeostasis Modulating Orthopedic Adhesive for the Closed‐Loop Management of Osteoporotic Fractures

Patients with osteoporotic fractures often require effective fixation and subsequent bone repair. However, currently available materials are often limited functionally, failing to improve this cohort's outcomes. Herein, kaempferol‐loaded mesoporous bioactive glass nanoparticles (MBGNs)‐doped orthopedic adhesives are prepared to assist osteoporotic fracture fixation and restore dysregulated bone homeostasis, including promoting osteoblast formation while inhibiting osteoclastic bone‐resorbing activity to synergistically promote osteoporotic fracture healing. The injectability, reversible adhesiveness and malleable properties endowed the orthopedic adhesives with high flexibility and hemostatic performance to adapt to complex clinical scenarios. Moreover, Ca2+ and SiO44− ions released from MBGNs can accelerate osteogenesis via the PI3K/AKT pathway, while kaempferol mediated osteoclastogenesis inhibition and can slow down the bone resorption process through NF‐κB pathway, which regulated bone regeneration and remodeling. Importantly, implementing the orthopedic adhesive is validated as an effective closed‐loop management approach in restoring the dysregulated bone homeostasis of osteoporotic fractures. The orthopedic GMOS/K@M adhesive excels in splicing fracture fragments and facilitating osteoporotic fracture fixation using a non‐invasive approach. GMOS/K@M adhesive, doped with mesoporous bioactive glass nanoparticles (MBGNs) and loaded with kaempferol, effectively treats osteoporotic fractures in a closed‐loop management by restoring bone homeostasis through pro‐osteogenic and anti‐osteoclastic effects.